GEO DataSet Links for PMC (Select 4208022) - GEO DataSets

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Items: 2

Select item 2000603491.

Inhibiting Monoacylglycerol Acyltransferase 1 Ameliorates Hepatic Metabolic Abnormalities, but not Inflammation and Injury in Mice

(Submitter supplied) Abnormalities in hepatic lipid metabolism are believed to play a critical role in the etiology of nonalcoholic steatohepatitis (NASH). Monoacylglycerol acyltransferase (MGAT) enzymes convert monoacylglycerol to diacylglycerol, which is the penultimate step in one pathway for triacylglycerol (TAG) synthesis. Hepatic expression of Mogat1, which encodes an MGAT enzyme, is increased in the livers of mice with hepatic steatosis and knocking down Mogat1 improves insulin sensitivity, but whether increased MGAT activity plays a role in the etiology of NASH is unclear. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS5425
Platform:: GPL6887
8 Samples

Download data: TXT

Series

Accession:: GSE60349

ID:: 200060349

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 54252.

Monoacylglycerol acyltransferase 1 deficiency effect on high-fat diet fed mice: liver

Analysis of liver from diet-induced obese males depleted for monoacylglycerol acyltransferase 1 (Mogat1) via intraperitoneal injections of antisense oligonucleotide directed against Mogat1. Results provide insight into the role of Mogat1 in the development of nonalcoholic steatohepatitis (NASH).