GEO DataSet Links for PMC (Select 4536023) - GEO DataSets

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Items: 2

Select item 2000661751.

Imporatance of substantial weight loss for altering gene expression during intensive cardiovascular lifestyle modification

(Submitter supplied) The objective of this study was to examine relationships between weight loss through changes in lifestyle and peripheral blood gene expression profiles. Substantial weight loss (-15.2+3.8%) in lifestyle participants was associated with improvement in selected cardiovascular risk factors and significant changes in peripheral blood gene expression from pre- to post-intervention: 132 unique genes showed significant expression changes related to immune function and inflammatory responses involving endothelial activation. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL571
480 Samples

Download data: CEL, CHP

Series

Accession:: GSE66175

ID:: 200066175

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000460972.

Expression data of Participants of Ornish intervention and Control group

(Submitter supplied) Intensive lifestyle modification is believed to mediate cardiovascular disease (CVD) risk through traditional pathways that affect endothelial function and progression of atherosclerosis; however, the extent, persistence, and clinical significance of molecular change during lifestyle modification are not well known. Our study reveals that gene expression signatures are significantly modulated by rigorous lifestyle behaviors and track with CVD risk profiles over time.