GEO DataSet Links for PMC (Select 4870001) - GEO DataSets

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Items: 2

Select item 2000704991.

Effect of Bmal1 pre-natal knockout on liver gene expression: time-series

(Submitter supplied) We use a conventional (pre-natal) Bmal1 KO (cKO) mouse strain to investigate the effect of circadian disruption on gene expression in the liver by comparing cKO mice with wild type (WT) mice using RNA-Seq. All mice were housed under 12h:12h LD conditions with free access to food and water. Three mice per genotype were sacrificed every 4 h for 20 h (6 time points). Illumina TruSeq Stranded mRNA Sample Prep Kit Set A was used for library construction and samples were sequenced on an Illumina HiSeq 2500. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
36 Samples

Download data: TXT

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Accession:: GSE70499

ID:: 200070499

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000704972.

Effect of Bmal1 post-natal knockout on liver gene expression: time-series

(Submitter supplied) Gene expression in the liver has been studied extensively in normal mice, but not in mice with circadian disruption. We use a tamoxifen-inducible Lox/Cre KO mouse strain with the most important clock gene knocked out, BMAL-1. The aim of this experiment was to study the effect of circadian disruption on gene expression in the liver by comparing conditional Bmal1 KO mice with WT mice using RNA-seq. All mice were housed under 12h:12h LD conditions with free access to food and water. more...