GEO DataSet Links for PMC (Select 7941181) - GEO DataSets

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Items: 2

Select item 2002444941.

Reduced insulin/IGF1 signaling prevents immune aging via ZIP-10/bZIP–mediated feedforward loop

(Submitter supplied) A hallmark of aging is immunosenescence, a decline in immune functions, which appeared to be inevitable in living organisms, includingCaenorhabditis elegans. Here, we show that genetic inhibition of the DAF-2/insulin/IGF-1 receptor drastically enhances immunocompetence in old age inC. elegans. We demonstrate that longevity-promoting DAF-16/FOXO and heat-shock transcription factor 1 (HSF-1) increase immunocompetence in olddaf-2(−)animals. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18245
4 Samples

Download data: TXT

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Accession:: GSE244494

ID:: 200244494

PubMed Full text in PMC Similar studies

Select item 2001378612.

FOXO and HSF1 rejuvenate immunity via positive feedback regulation of insulin/IGF-1 signaling

(Submitter supplied) A hallmark of aging is immunosenescence, a decline in immune function that appeared to be inevitable. Surprisingly, here we show that genetic inhibition of DAF-2/insulin/IGF-1 receptor drastically delays immunosenescence and even rejuvenates immunity in C. elegans. We find that p38 mitogen activated protein kinase (PMK-1), a key determinant of immunosenescence in wild-type, is dispensable for this rejuvenated immunity. more...