GEO DataSet Links for SRA (Select 12443414) - GEO DataSets

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Items: 2

Select item 3049113361.

SLE_Jurkat_RNA_TNFa_4

Organism:: Homo sapiens

Source name:: Jurkat cell line

Platform:: GPL24676
Series:: GSE143792

Download data: TXT

Sample

Accession:: GSM4911336

ID:: 304911336

SRA Run Selector

Select item 2001437922.

Global discovery of SLE genetic risk variant allelic enhancer activity

(Submitter supplied) Genome-wide association studies of Systemic Lupus Erythematosus (SLE) nominate 3,073 genetic variants at 91 risk loci. To systematically screen these variants for allelic transcriptional enhancer activity, we constructed a massively parallel reporter assays (MPRA) library comprising 12,396 DNA oligonucleotides containing the genomic context around every allele of each SLE variant. Transfection into Epstein-Barr virus-transformed B cell line GM12878 revealed 482 variants with enhancer activity, with 51 variants showing genotype-dependent (allelic) enhancer activity at 27 risk loci. more...