GEO DataSet Links for SRA (Select 13736208) - GEO DataSets

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Items: 2

Select item 3052021381.

Patient-derived GSC -BT12 shCTRL D11-

Organism:: Homo sapiens

Source name:: Patient-derived glioblastoma stem cell

Platform:: GPL18573
Series:: GSE169418

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Accession:: GSM5202138

ID:: 305202138

SRA Run Selector

Select item 2001694182.

Patient-derived glioblastoma stem cells transcriptome regulation by CD109

(Submitter supplied) Glioma stem cells (GSCs) drive propagation and therapeutic resistance of glioblastomas, the most aggressive diffuse brain tumor. However, the molecular mechanisms that maintain the stemness and promote therapy resistance remain poorly understood. Here we study CD109 – STAT3 axis as crucial for the maintenance of stemness and tumorigenicity of GSCs and as a mediator of chemoresistance. Mechanistically, CD109 physically interacts with glycoprotein 130 (GP130) to promote activation of the IL-6/STAT3 pathway in GSCs. more...