GEO DataSet Links for SRA (Select 14439408) - GEO DataSets

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Items: 2

Select item 3052902491.

CRISPRi_DolcettoSetB_Donor2_IL2_high

Organism:: Homo sapiens

Source name:: Primary CD4+ T cells

Platform:: GPL18573
Series:: GSE174255 GSE174292

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Accession:: GSM5290249

ID:: 305290249

SRA Run Selector

Select item 2001742552.

CRISPR activation and interference screens decode stimulation responses in primary human T cells [CRISPR]

(Submitter supplied) Regulation of cytokine production in stimulated T cells can be disrupted in autoimmunity, immunodeficiencies, and cancer. Systematic discovery of stimulation-dependent cytokine regulators requires both loss-of-function and gain-of-function studies, which have been challenging in primary human cells. We now report genome-wide CRISPR activation (CRISPRa) and interference (CRISPRi) screens in primary human T cells to identify gene networks controlling interleukin 2 and interferon gamma production. more...