GEO DataSet Links for SRA (Select 21630184) - GEO DataSets

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Items: 2

Select item 3061063321.

EVI1_input_HNT34_141211_SN583_0132_AC66ATACXX

Organism:: Homo sapiens

Source name:: acute myeloid leukemia cell line

Platform:: GPL16791
Series:: GSE202207 GSE202211

Download data: BIGWIG

Sample

Accession:: GSM6106332

ID:: 306106332

SRA Run Selector

Select item 2002022072.

Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia (ChIP-Seq)

(Submitter supplied) Detailed genomic and epigenomic analyses of MECOM (the MDS1 and EVI1 complex locus) have revealed that inversion or translocation of chromosome 3 at MECOM drive inv(3)/t(3;3) myeloid leukemias and revealed MECOM germline mutations in patients with MECOM-associated bone marrow failure syndromes. Here we identify a novel, previously unannotated oncogenic RNA-splicing derived isoform of EVI1 which is frequently present in inv(3)/t(3;3) AML and directly contributes to leukemic transformation. more...