GEO DataSet Links for SRA (Select 30183520) - GEO DataSets

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Items: 2

Select item 3078651941.

NAFLD patient, NAFLD activity score 2-3, fibrosis stage 1, biological replication 1

Organism:: Homo sapiens

Source name:: Liver

Platform:: GPL24676
Series:: GSE246221 GSE246223

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Accession:: GSM7865194

ID:: 307865194

SRA Run Selector

Select item 2002462212.

A Mouse Model for Metabolic Dysfunction-associated Steatotic Liver Disease and Hepatocellular Carcinoma [RNA-seq]

(Submitter supplied) The lack of an appropriate preclinical model of metabolic dysfunction-associated steatotic liver disease (MASLD) that recapitulates the whole disease spectrum impedes exploration of disease pathophysiology and the development of effective treatment strategies. Considering the fact that MASLD patients accompanying type 2 diabetes mellitus (T2DM) have high risk of developing metabolic dysfunction-associated steatohepatitis (MASH), advanced fibrosis, and HCC, we treated low-dose streptozotocin (STZ; 40 mg/kg) for 5 consecutive days and subsequently fed a high-fat diet (HFD) to male C57BL/6J mice at 7 weeks of age (STZ+HFD). more...