GEO DataSet Links for SRA (Select 317416) - GEO DataSets

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Items: 2

Select item 3010798121.

H3K36me3_DicerWT_R2

Organism:: Mus musculus

Source name:: Dicer f/f murine MSC cell line

Platform:: GPL13112
Series:: GSE44159 GSE44163

Download data: BED

Sample

Accession:: GSM1079812

ID:: 301079812

SRA Run Selector

Select item 2000441592.

Let-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts [ChIP-seq_histone]

(Submitter supplied) MicroRNAs (miRNAs) are critical to proliferation, differentiation, and development. Here, we characterize gene expression in murine Dicer-null adult mesenchymal stem cell lines, a fibroblast cell type. Loss of Dicer leads to de-repression of let-7 targets at levels that exceed 10-100 fold with increases in transcription. Direct and indirect targets of this miRNA belong to a mid-gestation embryonic program that encompasses known oncofetal genes as well as oncogenes not previously associated with an embryonic state. more...