GEO DataSet Links for SRA (Select 32830484) - GEO DataSets

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Items: 2

Select item 3082608941.

Negatively supercoiled pBR322 DNA cleaved by topo IV with cip replicate 1

Organism:: Cloning vector pBR322

Source name:: Synthetic plasmid

Platform:: GPL34464
Series:: GSE267149

Download data: TXT

Sample

Accession:: GSM8260894

ID:: 308260894

SRA Run Selector

Select item 2002671492.

Highly sensitive mapping of type II topoisomerase DNA cleavage sites with SHAN-seq

(Submitter supplied) Type II topoisomerases (topos) are a ubiquitous and essential class of enzymes that form transient enzyme-bound double-stranded breaks on DNA called cleavage complexes. The location and frequency of these cleavage complexes on DNA is important for cellular function, genomic stability, and a number of clinically important anticancer and antibacterial drugs, e.g., quinolones. We developed a simple high-accuracy end-sequencing (SHAN-seq) method to sensitively map type II topo cleavage complexes on DNA in vitro. more...