GEO DataSet Links for SRA (Select 3401038) - GEO DataSets

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Links from SRA

Items: 2

Select item 3023751681.

Sample_13_TET2mut_AML_5Aza_RNAseq2

Organism:: Homo sapiens

Source name:: AML ex vivo culture

Platform:: GPL16791
Series:: GSE89521

Download data: TXT

Sample

Accession:: GSM2375168

ID:: 302375168

SRA Run Selector

Select item 2000895212.

Rational targeting of cooperating layers of the epigenome yields enhanced therapeutic efficacy against AML

(Submitter supplied) Disruption of epigenetic regulation is a hallmark of Acute Myeloid Leukemia (AML), but therapeutic interventions are difficult by the interplay of epigenetic mechanisms controlling genomic elements. We hypothesized that concurrent targeting of aberrant promoter and enhancer epigenetic silencing improves efficacy against AML. To test this, we developed an ex vivo culturing system and treated 52 patient-derived AML with low-dose 5-Azacytidine and specific LSD1 inhibitors. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing