GEO DataSet Links for SRA (Select 5977126) - GEO DataSets

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Items: 2

Select item 3032882881.

mac53-I rep2

Organism:: Caenorhabditis elegans

Source name:: L1 worm

Platform:: GPL18245
Series:: GSE117222

Download data: XLS

Sample

Accession:: GSM3288288

ID:: 303288288

SRA Run Selector

Select item 2001172222.

WDR-23 and SKN-1 Nrf2 coordinate with the BLI-3 dual oxidase in response to iodide-triggered oxidative stress

(Submitter supplied) Excess iodide could lead to larve arrest to C. elegans, we screened for mutants that can survive in excess iodide and identified gain-of-function mutations in skn-1 and loss-of-function mutations in wdr-23 and bli-3. Genetic study uncover that wdr-23(lf) can interact with bli-3 mutations in a manner different from skn-1(gf). Transcriptome studies suggest that excess iodide causes developmental arrest largely independent of changes in gene expression, and wdr-23(lf) could affect the expression of a subset of genes by a mechanism different from SKN-1 activation.