GEO DataSet Links for SRA (Select 8684533) - GEO DataSets

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Items: 2

Select item 3039671931.

AO rep2

Organism:: Saccharopolyspora erythraea

Source name:: engineered strain, the end of exponential phase

Platform:: GPL26951
Series:: GSE134767

Download data: TSV

Sample

Accession:: GSM3967193

ID:: 303967193

SRA Run Selector

Select item 2001347672.

Physiological responses of Saccharopolyspora erythraea towards perturbation of intracellular ATP

(Submitter supplied) Saccharopolyspora erythraea is used for industrial-scale production of erythromycin. To explore the physiological role of co-factors in regulation of primary and secondary metabolism of S. erythraea, we initially overexpressed the endogenous F1-ATPase in an erythromycin high-producing strain, E3. The engineered strain is named EA. The F1-ATPase expression resulted in a lower [ATP]/[ADP] ratio, which was accompanied by a dramatic increased production of a reddish pigment and a decreased erythromycin production. more...