smith a[Author] - GEO DataSets

Search results

Items: 1 to 20 of 488

<< First< Prev

Page of 25

Select item 2002226101.

Small noncoding RNA expression in pre-cystic mouse kidneys after Pkd2 deletion.

(Submitter supplied) To identify differentially expressed small noncoding RNAs downstream of Pkd2 mutations that may regulate early cyst growth, we used tamoxifen-inducible CAG-Cre to induce Pkd2 deletion at postnatal day 2 and compared to wild-type mice at postnatal day 6 and 10.

Organism:: Mus musculus

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL23479
47 Samples

Download data: XLSX

Series

Accession:: GSE222610

ID:: 200222610

Select item 2002203222.

Gene expression in pre-cystic mouse kidneys after Pkd2 deletion.

(Submitter supplied) To identify early transcriptional changes downstream of Pkd2 mutations that promote cyst formation, we used tamoxifen-inducible CAG-Cre to induce Pkd2 deletion at postnatal day 2 and compared to wild-type mice at postnatal day 6 and 10. We then performed gene expression profiling analysis using data obtained from RNA-seq of whole mouse kidneys.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23479
48 Samples

Download data: CSV

Series

Accession:: GSE220322

ID:: 200220322

Select item 2002634143.

Non-coding cause of congenital heart defects: Abnormal RNA splicing with multiple isoforms as a mechanism for heterotaxy

(Submitter supplied) Heterotaxy is a disorder characterized by severe congenital heart defects (CHDs) and abnormal left-right patterning in other thoracic or abdominal organs. Clinical and research-based genetic testing has previously focused on evaluation of coding variants to identify causes of CHDs, leaving non-coding causes of CHDs largely unknown. Variants in the transcription factor Zinc finger of the cerebellum 3 (ZIC3) cause X-linked heterotaxy. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL26167 GPL24676
17 Samples

Download data: TXT

Series

Accession:: GSE263414

ID:: 200263414

PubMed

Select item 2002131684.

RNAseq analysis of blood from influenza infected patients and healthy controls, project SIG_2022

(Submitter supplied) Goals: Study responses in peripheral blood of patients infected with influenza virus and compare to healthy control. Results: Strong differential host reponse after infection was observed.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
41 Samples

Download data: TXT

Series

Accession:: GSE213168

ID:: 200213168

PubMed Analyze with GEO2R

Select item 2001963505.

RNAseq analysis of blood from influenza infected patients and healthy controls

(Submitter supplied) Gene expression changes in the blood was studied by RNAseq Results: Strong differential host reponse after infection with influenza virus compared to healthy controls project SIG_2020

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
69 Samples

Download data: TXT

Series

Accession:: GSE196350

ID:: 200196350

PubMed Analyze with GEO2R

Select item 2001585926.

RNAseq analysis of blood from influenza infected patients and healthy controls SIG-2018

(Submitter supplied) Gene expression changes in the blood was studied by RNAseq; project SIG-2018 Results: Strong differential host reponse after infection with influenza virus compared to healthy controls

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
74 Samples

Download data: TXT

Series

Accession:: GSE158592

ID:: 200158592

PubMed Analyze with GEO2R SRA Run Selector

Select item 2001556357.

RNAseq analysis of blood from influenza infected patients and healthy controls-SIG2019

(Submitter supplied) Gene expression changes in the blood was studied by RNAseq; project SIG-2019 Results: Strong differential host reponse after infection with influenza virus compared to healthy controls

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
79 Samples

Download data: TXT

Series

Accession:: GSE155635

ID:: 200155635

PubMed Analyze with GEO2R SRA Run Selector

Select item 2001674968.

MITF perturbation in A2058 Melanoma cell lines

(Submitter supplied) We performed bulk RNA-seq on cultured melanoma with up- and down- regulation of the master regulator MITF in A2058 human melanoma cells.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
12 Samples

Download data: TXT

Series

Accession:: GSE167496

ID:: 200167496

Analyze with GEO2R SRA Run Selector

Select item 2002709039.

Hypoxic Memory Mediates Prolonged Tumor Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL19057 GPL18573
8 Samples

Download data: H5

Series

Accession:: GSE270903

ID:: 200270903

PubMed

Select item 20027029510.

Hypoxic Memory Mediates Prolonged Tumor Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression [scRNA-seq]

(Submitter supplied) Hypoxia is a common feature of many solid tumors due to aberrant proliferation and angiogenesis that is associated with tumor progression and metastasis. Most of the well-known hypoxia effects are mediated through hypoxia-inducible factors (HIFs). Identification of the long-lasting effects of hypoxia beyond the immediate HIF-induced alterations could provide a better understanding of hypoxia-driven metastasis and potential strategies to circumvent it. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
4 Samples

Download data: H5, RDS

Series

Accession:: GSE270295

ID:: 200270295

PubMed

Select item 20026998411.

Hypoxic Memory Mediates Prolonged Tumor Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression [RNA-Seq]

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
4 Samples

Download data: TSV

Series

Accession:: GSE269984

ID:: 200269984

PubMed Analyze with GEO2R

Select item 20025398712.

PRC2-AgeIndex: a universal biomarker of aging and rejuvenation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platform:: GPL24676
19 Samples

Download data: BW

Series

Accession:: GSE253987

ID:: 200253987

PubMed Full text in PMC Similar studies

Select item 20025398513.

PRC2-AgeIndex: a universal biomarker of aging and rejuvenation [WGBS]

(Submitter supplied) DNA methylation (DNAm) is one of the most reliable biomarkers of aging across many mammalian tissues. While the age-dependent global loss of DNAm has been well characterized, age-dependent DNAm gain is less specified. Multiple studies have demonstrated that polycomb repressive complex 2 (PRC2) targets are enriched among the CpG sites which gain methylation with age. However, systematic whole-genome examination of all PRC2 targets in the context of aging methylome as well as determination of the pan-tissue or tissue-specific nature of these associations is lacking. more...

Organism:: Homo sapiens

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL24676
6 Samples

Download data: BW, TXT

Series

Accession:: GSE253985

ID:: 200253985

PubMed Full text in PMC Similar studies

Select item 20025377314.

PRC2-AgeIndex: a universal biomarker of aging and rejuvenation [ChIP-seq]

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24676
13 Samples

Download data: BW, NARROWPEAK

Series

Accession:: GSE253773

ID:: 200253773

PubMed Full text in PMC Similar studies

Select item 20026068715.

Single-nuclei characterization of oxycodone's effects on dorsal peduncular nucleus

(Submitter supplied) In addition to their intrinsic rewarding properties. opioids can also evoke aversive reactions that protect against misuse. Cellular mechanisms that govern the interplay between opioid reward and aversion are poorly understood. We used whole-brain activity mapping to show that neurons in the dorsal peduncular nucleus (DPn) are highly responsive to the opioid oxycodone. Connectomic profiling revealed that DPn neurons innervate the parabrachial nucleus (PBn). more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
4 Samples

Download data: H5

Series

Accession:: GSE260687

ID:: 200260687

PubMed Full text in PMC Similar studies

Select item 20026202716.

BET inhibition reforms the immune microenvironment and alleviates T-cell dysfunction in chronic lymphocytic leukemia

(Submitter supplied) Redundant tumor microenvironment (TME) immunosuppressive mechanisms and epigenetic maintenance of terminal T-cell exhaustion greatly hinder functional anti-tumor T-cell responses in chronic lymphocytic leukemia (CLL). Bromodomain and extra-terminal (BET) proteins regulate key pathways contributing to CLL pathogenesis and TME interactions, including T-cell function and differentiation. Herein, we report that blocking BET protein function alleviates immunosuppressive networks in the CLL TME and repairs inherent T-cell defects. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL34315
12 Samples

Download data: RCC

Series

Accession:: GSE262027

ID:: 200262027

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20026464817.

Characterization of premature cell senescence in Alzheimer’s disease using single nuclear transcriptomics

(Submitter supplied) Aging is associated with cell senescence and is the major risk factor for AD. We characterized premature cell senescence in post mortem brains from non-diseased controls (NDC) and donors with Alzheimer’s disease (AD) using imaging mass cytometry (IMC) and single nuclear RNA (snRNA) sequencing (>200,000 nuclei). We found increases in numbers of glia immunostaining for galactosidase beta (>4-fold) and p16INK4A (up to 2-fold) with AD relative to NDC. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
49 Samples

Download data: RDS

Series

Accession:: GSE264648

ID:: 200264648

Select item 20023623918.

Novel spirocyclic dimer, SpiD3, targets critical tumor survival pathways and displays potent preclinical activity in B-cell chronic lymphocytic leukemia

(Submitter supplied) Chronic lymphocytic leukemia (CLL) cell survival and growth is fueled by aberrant activation of various pro-survival signaling pathways within tumor niches. Specifically, B-cell receptor (BCR) signaling, toll-like receptor signaling, and supportive cellular interactions drive constitutive activation of NF-κB signaling and transcription of proliferative/pro-survival genes. Directly targeting the NF-κB pathway has been a challenge, however, herein, we investigated SpiD3, a spirocyclic dimer and novel NF-κB pathway inhibitor in preclinical models of CLL. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21697
9 Samples

Download data: XLSX

Series

Accession:: GSE236239

ID:: 200236239

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20025280519.

Dynamic co-evolution of transposable elements and the piRNA pathway in East African cichlid fishes

(Submitter supplied) East African cichlid fishes have diversified in an explosive fashion, but the (epi)genetic basis of the phenotypic diversity of these fishes remains largely unknown. Although transposable elements (TEs) have been associated with phenotypic variation in cichlids, little is known about their transcriptional activity and epigenetic silencing. Here, we describe dynamic patterns of TE expression in African cichlid gonads and during early development. more...