GEO DataSets

(Submitter supplied) Previous work has demonstrated that non-synonymous mutations in the gene encoding the putative transcription factor CpMrr1 can influence fluconazole susceptibility; however, the direct contribution of these mutations and how they influence fluconazole resistance in clinical isolates is poorly understood. We identified ten non-synonymous CpMRR1 mutations in a collection of 35 fluconazole resistant clinical isolates. more...

Organism:

Candida parapsilosis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL31926

18 Samples

Download data: CLC

(Submitter supplied) Pathogenic Candida fungi are a leading cause of opportunistic, hospital-associated bloodstream infections with high mortality rates, typically in immunocompromised patients. Several species, including C. albicans, the most prevalent cause of infection, belong to the monophyletic CUG clade of yeasts. Much is known about the interaction of C. albicans with innate immune cells, which are crucial for controlling infection. more...

Organism:

Candida tropicalis; Mus musculus; Candida dubliniensis; Candida albicans; Lodderomyces elongisporus; Candida parapsilosis; Clavispora lusitaniae

Type:

Expression profiling by high throughput sequencing

12 related Platforms

24 Samples

Download data: TXT

(Submitter supplied) The purpose of this experiment was to identify the genes bound by the biofilm master regulators (Bcr1, Brg1, Efg1, Ndt80, Rob1 and Tec2) in Candida albicans, C. dubliniensis, C. tropicalis and C. parapsilosis during biofilm formation. The regulators were tagged with a c-myc epitope and the immunoprecipitation of the tagged strain was compared to that of an untagged control strain.

Organism:

Candida tropicalis; Candida albicans; Candida parapsilosis; Candida dubliniensis

Type:

Genome binding/occupancy profiling by high throughput sequencing

6 related Platforms

61 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Candida albicans x Candida dubliniensis; Candida albicans; Candida parapsilosis; Candida tropicalis; Candida dubliniensis

Type:

Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

11 related Platforms

127 Samples

Download data: GPR, TXT

(Submitter supplied) Candida parapsilosis has emerged as a frequent cause of invasive candidiasis with increasing evidence of unique biological features relative to C. albicans. As it adapts to conditions within a mammalian host, rapid changes in gene expression are necessary to facilitate colonization and persistence in this environment. Adhesion of the organism to biological surfaces is a key first step in this process and is the focus of this study. more...

Organism:

Candida parapsilosis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18663

27 Samples

Download data: TXT

(Submitter supplied) Investigation of centromeres in the pathogenic yeast Candida parapsilosis, shows that the location of two centromeres are polymorphic within this species. The centromeres consist of large inverted repeats (IRs), surrounding unique sequences. New (neo) centromeres have emerged in one C. parapsilosis isolate even though the original CEN location is undamaged. The neocentromeres do not contain IRs, and have no obvious sequence features.

Organism:

Candida parapsilosis

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL27421

10 Samples

Download data: BIGWIG

(Submitter supplied) Candidiasis affects a wide variety of immunocompromised individuals, including HIV/AIDS patients and cancer patients on chemotherapy. Candida albicans, a major human fungal pathogen, accounts for about 50% of all cases, while the remainder are caused by the less pathogenic non-albicans Candida species (NACS). These species are believed to be less pathogenic, in part, because they do not filament as readily or robustly as C. more...

Organism:

Candida tropicalis; Candida parapsilosis

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL21876 GPL18663

16 Samples

Download data: TXT

(Submitter supplied) Tyrosol plays a key role in fungal morphogenesis and biofilm development. Also, it has a remarkable antifungal effect at supraphysiological concentrations. However, the background of the antifungal effect remains unknown, especially in the case of non-albicans Candida species such as Candida parapsilosis We examined the effect of tyrosol on the growth, adhesion, redox homeostasis, virulence, as well as on fluconazole susceptibility. more...

Organism:

Candida parapsilosis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24494

6 Samples

Download data: XLSX

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Candida albicans; Candida parapsilosis; Candida tropicalis; Nakaseomyces glabratus; Homo sapiens

Type:

Expression profiling by high throughput sequencing

5 related Platforms

75 Samples

Download data

(Submitter supplied) Homo sapiens fresh whole blood was infected with Candida parapsilosis. RNA-pool of both species extracted at 0min (control), 15, 30, 60, 120, 240 min. Samples are rRNA depleted. Measurement of Homo sapiens gene expression.

Organism:

Candida parapsilosis; Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24976

18 Samples

Download data: CSV

(Submitter supplied) Investigation of the role of HAC1 using transcriptional profiling of Candida parapsilosis treated with 5 mM dithiothreitol Gene expression of wild type and hac1 deletion strains were compared during growth in YPD only and growth in YPD with 5 mM DTT

Organism:

Candida parapsilosis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL25585

12 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Candida parapsilosis; Candida albicans; Planoprotostelium fungivorum; Nakaseomyces glabratus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL25268 GPL25267

18 Samples

Download data

(Submitter supplied) We investigated different escape and defense strategies of Candida parapsilosis against the natural fungivorous predator Protostelium aurantium using dual RNA-Seq. Trophozoites of the amoeba Protostelium aurantium were fed with C. parapsilosis and samples for RNA isolation were taken at time points 0 min (control), 30 min and 60 min. At indicated time points samples were shock frozen and used for RNA isolation. more...

Organism:

Candida parapsilosis; Planoprotostelium fungivorum

Type:

Expression profiling by high throughput sequencing

Platform:

GPL25268

9 Samples

Download data: TSV

(Submitter supplied) Transcriptional profiling of Candida parapsilosis in media with a preferred nitrogen source (ammonium sulfate) and a non-preferred source (isoleucine) to identify genes that are subject to Nitrogen Catabolite Expression. Gene expression of wild type and dal81 deletion strains were compared during growth in complex nitrogen sources (YPD), in minimal media with a preferred nitrogen source (YNB+ammonium sulfate) and minimal medium with a non-preferred source (GABA).

Organism:

Candida parapsilosis

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL24494 GPL24493

24 Samples

Download data: TXT

(Submitter supplied) The present study describes a novel mechanism of antifungal resistance affecting the susceptibility of both the azole and echinocandin antifungals in an azole-resistant isolate from a matched pair of C. parapsilosis isolates obtained from a patient with prosthetic valve endocarditis. Transcriptome analysis indicated differential expression of several genes in the resistant isolate including upregulation of ERG1, ERG2, ERG5, ERG6, ERG11, ERG24, ERG25, ERG27, DAP1 and UPC2, of the ergosterol biosynthesis pathway. more...

Organism:

Candida parapsilosis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23488

4 Samples

Download data: CSV, XLSX

(Submitter supplied) Abstract: Candida parapsilosis and Candida albicans are human fungal pathogens that belong to the CUG clade in the Saccharomycotina. In contrast to C. albicans, relatively little is known about the virulence properties of C. parapsilosis, a pathogen particularly associated with infections of premature neonates. We describe here the construction of >200 C. parapsilosis strains carrying double allele deletions of transcription factors, protein kinases and species-specific genes. more...

Organism:

Candida parapsilosis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18663

24 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Candida parapsilosis

Type:

Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:

GPL16091

14 Samples

Download data

(Submitter supplied) In Candida albicans the Efg1 transcription factor (a member of the APSES family) is an important regulator of hyphal growth, and of the white-to-opaque transition. In contrast, we show that the Efg1 ortholog in Candida parapsilosis is a major regulator of a different morphological switch at the colony level, from a concentric to smooth morphology. The rate of switching is at least 100-fold increased in an efg1 knockout relative to wild type. more...

Organism:

Candida parapsilosis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16091

8 Samples

Download data: TXT

(Submitter supplied) We use ChIP-seq to identify the targets of Efg1 in Candida parapsilosis. We show that Efg1 binds to 502 promoter regions, including 70 potential transcription factors or regulatory proteins. Several of the transcription factors belong to networks that regulate biofilm development and white-opaque switching in C. albicans. Efg1 also binds to its own promoter. The binding site for C. parapsilosis Efg1 resembles that of orthologs in other fungi. more...

Organism:

Candida parapsilosis

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL16091

6 Samples

Download data: FASTA, TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Candida parapsilosis

Type:

Expression profiling by array; Expression profiling by high throughput sequencing

Platforms:

GPL13192 GPL14718

34 Samples

Download data: GPR, SAM