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Items: 1 to 20 of 18522

1.

Obesity regulates the fate of peripheral blood mononuclear cells through FoxM1

(Submitter supplied) Obesity is associated with various diseases such as metabolic disorders, joint problems, and inflammations. Over 50% of pets, including dogs and cats, are obese, making a comparative study necessary at gene level. Since circulating peripheral blood mononuclear cells (PBMCs) reflect the organs related to obesity, we compared the mRNA expression in normal and obese PBMCs of dogs. Our findings show that there are 425 differentially expressed genes (DEGs) (p < 0.05, |log2 fold| ≥ 1) that exhibit distinct gene expression between normal and obese PBMCs. more...
Organism:
Canis lupus familiaris
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28490
8 Samples
Download data: TXT
Series
Accession:
GSE269477
ID:
200269477
2.

Single cell sequencing of hypoimmunogenic neonatal islet beta cells

(Submitter supplied) In this study, 7530 newborn pancreatic β-cells were analyzed by single-cell sequencing. Cell Ranger was used to compare the original sequencing data, count the genome, filter background cells and cell transcript UMI, and use cell barcode to generate gene-barcode matrix. Then the samples were grouped, gene expression analysis, etc., and the statistical results of each sample sequencing data were output
Organism:
Canis lupus familiaris
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20988
1 Sample
Download data: MTX, TSV
Series
Accession:
GSE267867
ID:
200267867
3.

Wildtype and PALS1 knockout MDCKII cells grown under non-confluent and in 3D cyst cultures

(Submitter supplied) To investigate how gradual differences in the tight junction formation could be linked to an altered gene expression, wildtype and PALS1 knockout cell lines were grown under non-confluent and in 3D cyst cultures. After preparation of the mRNA samples, mRNASeq was performed. Normalized gene expression data was then was analyzed for differentially expressed genes, and GO-Term enrichment studies were used to elucidate involved pathways.
Organism:
Canis lupus familiaris
Type:
Expression profiling by high throughput sequencing
Platform:
GPL33053
22 Samples
Download data: TXT
Series
Accession:
GSE264311
ID:
200264311
4.

Differential expression of genes upon E-cadherin loss of function

(Submitter supplied) In this work by growing monolayers upto 70-80% confluency we study the differential expression of genes upon E-cadherin loss of function
Organism:
Canis lupus familiaris
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21400
6 Samples
Download data: XLSX
Series
Accession:
GSE234079
ID:
200234079
5.

Gene expression profile at single cell level of gingiva and alveolar bone tissues of canines with peri-implantitis and healthy conditions

(Submitter supplied) Peri-implantitis is a common complication characterized by chronic inflammation of the periodontal tissue. This disease is marked by irreversible and progressive degradation of the gingiva and alveolar bone, ultimately leading to tooth loss.Most current research has focused on the entire periodontal tissue, which restricts a comprehensive understanding of the heterogeneity between gingiva and bone tissues, and hinders the development of targeted host therapies for peri-implantitis. more...
Organism:
Canis lupus familiaris
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16540
4 Samples
Download data: MTX, TSV
Series
Accession:
GSE281266
ID:
200281266
6.

A study of the effects of bisphenol A on dog obesity

(Submitter supplied) The transcriptomic changes caused by BPA on canine adipose-derived stem cells (cADSCs) during differentiation were investigated in this study. The transcriptomic profiles were investigated using RNA-sequencing.
Organism:
Canis lupus familiaris
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25760
6 Samples
Download data: TXT
Series
Accession:
GSE207623
ID:
200207623
7.

Whole blood gene expression analysis of spontaneous hypertriglyceridemia in dogs suggests an underlying pro-thrombotic process

(Submitter supplied) Hypertriglyceridemia (HTG) is influenced by multiple genetic and environmental factors. Spontaneous, idiopathic HTG is common in the Miniature Schnauzer dog and presumed to have a strong genetic influence in this breed. To define genes that are differentially expressed in dogs with HTG, we performed RNA sequencing on peripheral blood of 13 Miniature Schnauzers with HTG and 18 controls. We identified 110 differentially expressed genes (DEGs). more...
Organism:
Canis lupus familiaris
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25760
31 Samples
Download data: TXT
Series
Accession:
GSE242034
ID:
200242034
8.

Whole-genome bisulfite sequencing in the whole blood of three dog breeds

(Submitter supplied) DNA methylation patterns reflect the status of individual tissues, such as cell composition, age, and the local environment in mammals. This experiment addressed the DNA methylation landscape in the dog genome across three breeds: Shiba, Dachshund (Miniature), and Poodle (Toy). A comprehensive profile of whole-genome DNA methylation from the whole blood of three dog breeds was generated using whole-genome bisulfite sequencing.
Organism:
Canis lupus familiaris
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL25760
19 Samples
Download data: TDF
Series
Accession:
GSE252908
ID:
200252908
9.

Preclinical evaluation of aluminum hydroxide-tethered interleukin-12 (JEN-101) therapy in pet dogs with advanced malignant melanoma

(Submitter supplied) A Phase I study was conducted to determine the tolerability, activity, and immune responses of JEN-101 in dogs with advanced melanoma. A 3+3 dose escalation design was used to evaluate intratumoral injection of JEN-101 at 1, 3, 10, or 20 μg/kg every three weeks for four cycles. A second course was allowable in the absence of disease progression or toxicity. Peripheral blood, serum, and tumor biopsies were collected at baseline and at pre-specified timepoints for pharmacokinetic and immune analyses, which included serum cytokines, immunohistochemistry, and gene expression assessment. more...
Organism:
Canis lupus familiaris
Type:
Expression profiling by array
Platform:
GPL32796
21 Samples
Download data: CSV
Series
Accession:
GSE278391
ID:
200278391
10.

A genotype-first approach identifies variants for orofacial clefts and other phenotypes in dogs

(Submitter supplied) Dog breeding promotes within-group homogeneity through conformation to strict breed standards and also drives between-group heterogeneity in pursuit of distinct morphological forms and characteristic breed traits. In this study, the genotype-first approach was adapted to the dog genome to investigate coding variation from over 2000 dogs, leading to discoveries of new mutations related to craniofacial morphology and stature. more...
Organism:
Canis lupus familiaris
Type:
Methylation profiling by array
Platform:
GPL17481
308 Samples
Download data: IDAT, TXT, XLSX
Series
Accession:
GSE278600
ID:
200278600
11.

Genomic reconstruction of Galápagos dog history reveals strategies for management of an invasive species

(Submitter supplied) Free-breeding dogs have occupied the Galápagos islands at least since the 1830s, however, it was not until the 1900s that dog populations grew substantially, endangering wildlife and spreading disease. In 1981, authorities sanctioned the culling of free-roaming dogs. Yet there are currently large free-roaming dog populations of unknown ancestry on the islands of Isabela and Santa Cruz, whose ancestry has never been assessed on a genome-wide scale. more...
Organism:
Canis lupus familiaris
Type:
SNP genotyping by SNP array; Genome variation profiling by SNP array
Platform:
GPL17481
187 Samples
Download data: IDAT, TXT
Series
Accession:
GSE276576
ID:
200276576
12.

Single cell gene expression profile for normal adult canine neuroretina

(Submitter supplied) Retinal single cell gene expression profile from two male dogs at 40 weeks of age.
Organism:
Canis lupus familiaris
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21400
2 Samples
Download data: MTX, TSV
Series
Accession:
GSE271945
ID:
200271945
13.

Multiomics analysis of canine myocardium after circumferential pulmonary vein ablation: Effect of NPY on long-term reinduction of atrial fibrillation

(Submitter supplied) In this study,We established a long-term model of beagle canines after circumferential pulmonary vein ablation (CPVA). The transcriptome and proteome were obtained using high-throughput sequencing and TMT-tagged LC‒MS/LC analysis. Differentially expressed genes and proteins were screened and enriched, and the effect of fibrosis was found and verified in tissues
Organism:
Canis lupus familiaris
Type:
Expression profiling by high throughput sequencing
Platform:
GPL33670
10 Samples
Download data: XLS
Series
Accession:
GSE248285
ID:
200248285
14.

miR-182, miR-221 and miR-222 are potential urinary extracellular vesicle biomarkers for canine urothelial carcinoma

(Submitter supplied) Urothelial carcinoma (UC) is the most common tumour type in canine bladder cancer. Current diagnostic methods are technically challenging or can lack specificity, hence there is a need for novel biomarkers of UC. To this end, we analysed the microRNA (miRNA) cargo of extracellular vesicles (EVs) from urine samples of dogs with UC to identify miRNAs that could be utilised as biomarkers. Urine was fractionated using ultrafiltration combined with size-exclusion chromatography and small RNA sequencing analysis was performed on both the EV enriched and (EV free) protein fractions. more...
Organism:
Canis lupus familiaris
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL25760
56 Samples
Download data: CSV
Series
Accession:
GSE256461
ID:
200256461
15.

Host-Microbe Interactions in the Nasal Cavity of Dogs with Chronic Idiopathic Rhinitis

(Submitter supplied) Chronic rhinitis (CR) is a frustrating clinical syndrome in dogs and our understanding of the disease pathogenesis in is limited. Increasingly, host-microbe interactions are considered key drivers of clinical disease in sites of persistent mucosal inflammation such as the nasal and oral cavities. Therefore, we applied next generation sequencing tools to interrogate abnormalities present in the nose of dogs with CR and compared immune and microbiome profiles to those of healthy dogs. more...
Organism:
Canis lupus familiaris
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24229
12 Samples
Download data: TXT
Series
Accession:
GSE255529
ID:
200255529
16.

Analysis of gene expression in the dog macular retina and supporting tissues: comparison with human macular gene expression profiles

(Submitter supplied) Dogs are commonly used models of human inherited retinal disorders. Because the dog retina contains a macula-like region, dogs are susceptible to maculopathies with many shared genetic etiologies with humans. Human macular gene expression has been characterized and provides insight into the underlying basis of macular disease. We sought to compare macular gene expression profiles in dogs and humans and interrogate macular disease-associated genes for differential expression between macula and periphery. more...
Organism:
Canis lupus familiaris
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20988
22 Samples
Download data: TXT
Series
Accession:
GSE227619
ID:
200227619
17.

Deconstruction of cellular dynamics after treatment of volumetric muscle loss injury with extracellular matrix

(Submitter supplied) Volumetric muscle loss (VML) is an acute loss of a critical volume of skeletal muscle that results in inflammation, fibrotic scarring in muscle tissue, and permanent muscle defects. The cellular and molecular processes that underlie fibrosis induced from VML injury need to be evaluated in larger animal models. Therefore, we used a canine model of VML alongisde treatment with an extracellular matrix (ECM) hydrogel. more...
Organism:
Canis lupus familiaris
Type:
Other
Platform:
GPL25760
17 Samples
Download data: RDS
Series
Accession:
GSE266585
ID:
200266585
18.

Stromal expression profiling reveals immune-driven adaption to malignancy in canine melanoma subtypes

(Submitter supplied) Canine mucosal melanoma (CMM) is the most common oral malignancy in dogs and exhibits significantly higher aggressiveness than its cutaneous counterpart (CCM), yet the reasons for this disparity remain unclear. The influence of cancer-associated stroma (CAS) on tumour progression is well-recognized, but a detailed understanding of CAS in canine melanoma is missing. To comprehensively assess stromal reprogramming in canine melanoma, we analysed CAS from 21 CMM, 14 CCM and normal stroma from 10 skin and 9 oral mucosa samples by laser-capture microdissection followed by RNA sequencing. more...
Organism:
Canis lupus familiaris
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25760
54 Samples
Download data: XLSX
Series
Accession:
GSE266234
ID:
200266234
19.

Single-Cell RNA Sequencing Investigation of the Duodenal Mucosa in Canine Chronic Inflammatory Enteropathy and Health

(Submitter supplied) We used single-cell RNA sequencing to characterize the heterogeneity duodenal tissue in healthy and chronic inflammatory enteropathy (CIE) affected dogs.
Organism:
Canis lupus familiaris
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25760
7 Samples
Download data: MTX, TSV
Series
Accession:
GSE254005
ID:
200254005
20.

Spatial gene expression of canine veins during carotid-cartoid vein bypass implantation

(Submitter supplied) Vein graft failure (VGF) following cardiovascular bypass surgery results in significant patient morbidity and cost to the healthcare system. Vein graft injury can occur during autogenous vein harvest and preparation, as well as after implantation into the arterial system, leading to the development of intimal hyperplasia, vein graft stenosis, and, ultimately, bypass graft failure. While previous studies have identified maladaptive pathways that occur shortly after implantation, the specific signaling pathways that occur during vein graft preparation are not well defined and may result in a cumulative impact on VGF. more...
Organism:
Canis lupus familiaris
Type:
Other
Platform:
GPL25760
8 Samples
Download data: MTX, TAR, TSV
Series
Accession:
GSE263281
ID:
200263281
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