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msi2a musashi RNA-binding protein 2a [ Danio rerio (zebrafish) ]

Gene ID: 100002680, updated on 4-Jan-2025

Summary

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Official Symbol
msi2aprovided by ZNC
Official Full Name
musashi RNA-binding protein 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030826-25
See related
Ensembl:ENSDARG00000033901 AllianceGenome:ZFIN:ZDB-GENE-030826-25
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
msi2; cb746; fi47b09; wu:fb02d08; wu:fi32d12; wu:fi47b09
Summary
Predicted to enable RNA binding activity. Is expressed in cranial ganglion; diencephalon; hindbrain; tegmentum; and telencephalon. Orthologous to human MSI2 (musashi RNA binding protein 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See msi2a in Genome Data Viewer
Location:
chromosome: 10
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (37500186..37784862)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (37556399..37841104)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene si:dkey-65j4.2 Neighboring gene A kinase (PRKA) anchor protein 1a Neighboring gene uncharacterized LOC137490697 Neighboring gene uncharacterized LOC103911773 Neighboring gene nucleolar protein 58-like Neighboring gene nucleolar protein 58-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish stem/progenitor factor msi2b exhibits two phases of activity mediated by different splice variants. Hochgreb-Hägele T, et al. Stem Cells, 2014 Feb. PMID 24420905, Free PMC Article
  2. A Multifunctional Mutagenesis System for Analysis of Gene Function in Zebrafish. Quach HN, et al. G3 (Bethesda), 2015 Apr 2. PMID 25840430, Free PMC Article
  3. A spinal organ of proprioception for integrated motor action feedback. Picton LD, et al. Neuron, 2021 Apr 7. PMID 33577748
  4. Lef1-dependent hypothalamic neurogenesis inhibits anxiety. Xie Y, et al. PLoS Biol, 2017 Aug. PMID 28837622, Free PMC Article
  5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC55422

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RNA-binding protein Musashi homolog 2a
Names
musashi homolog 2
musashi homolog 2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320102.1 → NP_001307031.1  RNA-binding protein Musashi homolog 2a

    Status: VALIDATED

    Source sequence(s)
    CK027672, CR931806, EH471460
    UniProtKB/TrEMBL
    F6NI68, F6P9C3, Q7ZW10
    Related
    ENSDARP00000123512.1, ENSDART00000132096.3
    Conserved Domains (3) summary
    COG0724
    Location:2 → 162
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12323
    Location:111 → 184
    RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:23 → 97
    RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    37500186..37784862
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009305537.4 → XP_009303812.1  RNA-binding protein Musashi homolog 2a isoform X1

    UniProtKB/TrEMBL
    A0A8M3AX32
    Conserved Domains (3) summary
    COG0724
    Location:2 → 162
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12323
    Location:111 → 184
    RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:23 → 97
    RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394796.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    95171..263204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395293.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    46658..163641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_212796.1: Suppressed sequence

    Description
    NM_212796.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version

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