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p4ha1b prolyl 4-hydroxylase, alpha polypeptide I b [ Danio rerio (zebrafish) ]

Gene ID: 100003675, updated on 2-Nov-2024

Summary

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Official Symbol
p4ha1bprovided by ZNC
Official Full Name
prolyl 4-hydroxylase, alpha polypeptide I bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-4089
See related
Ensembl:ENSDARG00000071082 AllianceGenome:ZFIN:ZDB-GENE-030131-4089
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
p4ha1; zgc:56058; wu:fc69d06; wu:fi27h11
Summary
Predicted to enable procollagen-proline 4-dioxygenase activity. Predicted to be involved in collagen fibril organization. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum. Orthologous to human P4HA1 (prolyl 4-hydroxylase subunit alpha 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See p4ha1b in Genome Data Viewer
Location:
chromosome: 17
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (20147402..20167127, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (20127566..20147365, complement)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene ryanodine receptor 2b (cardiac) Neighboring gene actinin, alpha 2b Neighboring gene si:ch211-248a14.8 Neighboring gene ecdysoneless homolog (Drosophila) Neighboring gene gonadotropin-releasing hormone 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Growth hormone overexpression generates an unfavorable phenotype in juvenile transgenic zebrafish under hypoxic conditions. Almeida DV, et al. Gen Comp Endocrinol, 2013 Dec 1. PMID 24055561
  2. Glucocorticoids promote Von Hippel Lindau degradation and Hif-1α stabilization. Vettori A, et al. Proc Natl Acad Sci U S A, 2017 Sep 12. PMID 28851829, Free PMC Article
  3. Deficiency of a transmembrane prolyl 4-hydroxylase in the zebrafish leads to basement membrane defects and compromised kidney function. Hyvärinen J, et al. J Biol Chem, 2010 Dec 31. PMID 20952382, Free PMC Article
  4. Genome-wide mapping of Hif-1α binding sites in zebrafish. Greenald D, et al. BMC Genomics, 2015 Nov 11. PMID 26559940, Free PMC Article
  5. Transcriptional events co-regulated by hypoxia and cold stresses in Zebrafish larvae. Long Y, et al. BMC Genomics, 2015 May 15. PMID 25975375, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC56058

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables L-ascorbic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
enables procollagen-proline 4-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables procollagen-proline 4-dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in collagen fibril organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
prolyl 4-hydroxylase subunit alpha-1b
Names
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I
NP_999856.1
XP_009291233.1
XP_068070400.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214691.1 → NP_999856.1  prolyl 4-hydroxylase subunit alpha-1b precursor

    See identical proteins and their annotated locations for NP_999856.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045890
    UniProtKB/TrEMBL
    A0A8M1PHF8, Q7ZVE9
    Related
    ENSDARP00000095644.3, ENSDART00000104874.4
    Conserved Domains (4) summary
    smart00702
    Location:347 → 520
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    sd00006
    Location:164 → 199
    TPR; TPR repeat [structural motif]
    pfam08336
    Location:24 → 153
    P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
    pfam13432
    Location:168 → 238
    TPR_16; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    20147402..20167127 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009292958.4 → XP_009291233.1  prolyl 4-hydroxylase subunit alpha-1b isoform X1

    UniProtKB/TrEMBL
    A0A2R8RN68, A0A8M3AJP6
    Related
    ENSDARP00000149102.1, ENSDART00000191995.1
    Conserved Domains (4) summary
    smart00702
    Location:347 → 520
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    sd00006
    Location:164 → 199
    TPR; TPR repeat [structural motif]
    pfam08336
    Location:24 → 153
    P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
    pfam13432
    Location:168 → 238
    TPR_16; Tetratricopeptide repeat

  2. XM_068214299.1 → XP_068070400.1  prolyl 4-hydroxylase subunit alpha-1b isoform X2

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394981.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    122705..142249 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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