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prrg2 proline rich Gla (G-carboxyglutamic acid) 2 [ Danio rerio (zebrafish) ]

Gene ID: 100005937, updated on 4-Jan-2025

Summary

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Official Symbol
prrg2provided by ZNC
Official Full Name
proline rich Gla (G-carboxyglutamic acid) 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-130625-1
See related
Ensembl:ENSDARG00000087193 AllianceGenome:ZFIN:ZDB-GENE-130625-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable calcium ion binding activity. Predicted to be located in extracellular region and membrane. Orthologous to human PRRG2 (proline rich and Gla domain 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See prrg2 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (32417032..32424303)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (32285318..32292589)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene si:ch211-195b15.8 Neighboring gene RAS related Neighboring gene proline rich 12b Neighboring gene si:ch211-195b15.7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane gamma-carboxyglutamic acid protein 2
Names
transmembrane gamma-carboxyglutamic acid protein 2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001202477.1 → NP_001189406.1  transmembrane gamma-carboxyglutamic acid protein 2 precursor

    See identical proteins and their annotated locations for NP_001189406.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4 encoded the same protein.
    Source sequence(s)
    EH544538, EH564701
    UniProtKB/TrEMBL
    A0A8M1P3K7, X1WF92
    Related
    ENSDARP00000128687.1, ENSDART00000154267.3
    Conserved Domains (1) summary
    smart00069
    Location:29 → 91
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues

  2. NM_001202478.1 → NP_001189407.1  transmembrane gamma-carboxyglutamic acid protein 2 precursor

    See identical proteins and their annotated locations for NP_001189407.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encoded the same protein.
    Source sequence(s)
    DY568170, EH544538, EH564701
    UniProtKB/TrEMBL
    A0A8M1P3K7, X1WF92
    Related
    ENSDARP00000128896.1, ENSDART00000155860.3
    Conserved Domains (1) summary
    smart00069
    Location:29 → 91
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues

  3. NM_001202479.1 → NP_001189408.1  transmembrane gamma-carboxyglutamic acid protein 2 precursor

    See identical proteins and their annotated locations for NP_001189408.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encoded the same protein.
    Source sequence(s)
    EH547250, EH550018, EH564701
    UniProtKB/TrEMBL
    A0A8M1P3K7, X1WF92
    Related
    ENSDARP00000151060.1, ENSDART00000186094.1
    Conserved Domains (1) summary
    smart00069
    Location:29 → 91
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues

  4. NM_001202480.1 → NP_001189409.1  transmembrane gamma-carboxyglutamic acid protein 2 precursor

    See identical proteins and their annotated locations for NP_001189409.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encoded the same protein.
    Source sequence(s)
    EH550018, EH564701
    UniProtKB/TrEMBL
    A0A8M1P3K7, X1WF92
    Related
    ENSDARP00000127859.1, ENSDART00000157324.3
    Conserved Domains (1) summary
    smart00069
    Location:29 → 91
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    32417032..32424303
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068215333.1 → XP_068071434.1  transmembrane gamma-carboxyglutamic acid protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M1P3K7, X1WF92
    Related
    ENSDARP00000129845.1, ENSDART00000156986.2
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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