U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

mark2b MAP/microtubule affinity-regulating kinase 2b [ Danio rerio (zebrafish) ]

Gene ID: 100005996, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
mark2bprovided by ZNC
Official Full Name
MAP/microtubule affinity-regulating kinase 2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-080215-4
See related
Ensembl:ENSDARG00000032458 AllianceGenome:ZFIN:ZDB-GENE-080215-4
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
mark2
Summary
Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in dendrite. Orthologous to human MARK2 (microtubule affinity regulating kinase 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See mark2b in Genome Data Viewer
Location:
chromosome: 7
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (24888898..24977161)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (24617687..24705846)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene adenosine deaminase domain containing 2 Neighboring gene kelch repeat-containing protein Neighboring gene REST corepressor 2 Neighboring gene N-alpha-acetyltransferase 40, NatD catalytic subunit

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes. Burguera D, et al. Nat Commun, 2017 Nov 27. PMID 29180615, Free PMC Article
  2. Repertoire of protein kinases encoded in the genome of zebrafish shows remarkably large population of PIM kinases. Rakshambikai R, et al. J Bioinform Comput Biol, 2014 Feb. PMID 24467753
  3. Dynamics of zebrafish fin regeneration using a pulsed SILAC approach. Nolte H, et al. Proteomics, 2015 Feb. PMID 25504979
  4. Protein kinase C family evolution in jawed vertebrates. Garcia-Concejo A, et al. Dev Biol, 2021 Nov. PMID 34329618
  5. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
serine/threonine-protein kinase MARK2
Names
MAP/microtubule affinity-regulating kinase 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    24888898..24977161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009303144.4 → XP_009301419.1  serine/threonine-protein kinase MARK2 isoform X1

    UniProtKB/TrEMBL
    A0A8M3BAY8
    Conserved Domains (4) summary
    smart00220
    Location:49 → 301
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14406
    Location:319 → 360
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:48 → 301
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    cl17070
    Location:691 → 789
    AMPKA_C_like; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha subunit and similar domains

  2. XM_017357016.3 → XP_017212505.1  serine/threonine-protein kinase MARK2 isoform X3

    UniProtKB/TrEMBL
    A0A8M6Z7T9

  3. XM_009303148.4 → XP_009301423.1  serine/threonine-protein kinase MARK2 isoform X8

    UniProtKB/TrEMBL
    A0A8M3AU67
    Conserved Domains (4) summary
    smart00220
    Location:49 → 301
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14406
    Location:319 → 360
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:48 → 301
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    cl17070
    Location:678 → 776
    AMPKA_C_like; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha subunit and similar domains

  4. XM_009303146.4 → XP_009301421.1  serine/threonine-protein kinase MARK2 isoform X4

    UniProtKB/TrEMBL
    A0A8M3B425
    Conserved Domains (4) summary
    smart00220
    Location:49 → 301
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14406
    Location:319 → 360
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:48 → 301
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    cl17070
    Location:682 → 780
    AMPKA_C_like; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha subunit and similar domains

  5. XM_009303147.4 → XP_009301422.1  serine/threonine-protein kinase MARK2 isoform X6

    UniProtKB/TrEMBL
    A0A8M3B152
    Conserved Domains (4) summary
    smart00220
    Location:49 → 301
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14406
    Location:319 → 360
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:48 → 301
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    cl17070
    Location:681 → 779
    AMPKA_C_like; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha subunit and similar domains

  6. XM_009303149.4 → XP_009301424.1  serine/threonine-protein kinase MARK2 isoform X9

    UniProtKB/TrEMBL
    A0A8M3BAZ3
    Conserved Domains (4) summary
    smart00220
    Location:49 → 301
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14406
    Location:319 → 360
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:48 → 301
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    cl17070
    Location:669 → 767
    AMPKA_C_like; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha subunit and similar domains

  7. XM_009303150.4 → XP_009301425.1  serine/threonine-protein kinase MARK2 isoform X11

    UniProtKB/TrEMBL
    A0A8M3AU60
    Conserved Domains (4) summary
    smart00220
    Location:49 → 301
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14406
    Location:319 → 360
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:48 → 301
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    cl17070
    Location:642 → 740
    AMPKA_C_like; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha subunit and similar domains

  8. XM_009303151.4 → XP_009301426.1  serine/threonine-protein kinase MARK2 isoform X12

    UniProtKB/TrEMBL
    A0A8M3B429
    Conserved Domains (4) summary
    smart00220
    Location:49 → 301
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14406
    Location:319 → 360
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:48 → 301
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    cl17070
    Location:632 → 730
    AMPKA_C_like; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha subunit and similar domains

  9. XM_068222600.1 → XP_068078701.1  serine/threonine-protein kinase MARK2 isoform X13

  10. XM_009303145.4 → XP_009301420.1  serine/threonine-protein kinase MARK2 isoform X2

    UniProtKB/TrEMBL
    A0A8M3AU54
    Related
    ENSDARP00000142972.1, ENSDART00000173994.2
    Conserved Domains (4) summary
    smart00220
    Location:49 → 300
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14406
    Location:318 → 359
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:48 → 300
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    cl17070
    Location:690 → 788
    AMPKA_C_like; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha subunit and similar domains

  11. XM_068222597.1 → XP_068078698.1  serine/threonine-protein kinase MARK2 isoform X5

    Related
    ENSDARP00000003234.8, ENSDART00000005329.8

  12. XM_068222598.1 → XP_068078699.1  serine/threonine-protein kinase MARK2 isoform X7

  13. XM_068222599.1 → XP_068078700.1  serine/threonine-protein kinase MARK2 isoform X10

    Related
    ENSDARP00000135887.2, ENSDART00000159955.2

  14. XM_068222601.1 → XP_068078702.1  serine/threonine-protein kinase MARK2 isoform X14

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.