irge4 immunity-related GTPase family, e4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: irge4provided by ZNC
Official Full Name: immunity-related GTPase family, e4provided by ZNC
Primary source: ZFIN:ZDB-GENE-051212-2
See related: Ensembl:ENSDARG00000070317 AllianceGenome:ZFIN:ZDB-GENE-051212-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:158767
Summary: Predicted to enable GTP binding activity and GTPase activity. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in inflammatory bowel disease 19 and tuberculosis. Orthologous to human IRGM (immunity related GTPase M). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (25822455..25829840, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (25907423..25914747, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: immunity-related GTPase family, e4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083032.1 → NP_001076501.1 immunity-related GTPase family, e4

See identical proteins and their annotated locations for NP_001076501.1

Status: PROVISIONAL

Source sequence(s)

BC133155

UniProtKB/TrEMBL

A2RV34

Related

ENSDARP00000080736.4, ENSDART00000086301.5

Conserved Domains (2) summary

COG1100
Location:39 → 261

Gem1; GTPase SAR1 family domain [General function prediction only]

cl21455
Location:41 → 231

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases