U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

mpz.S myelin protein zero S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 100037196, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
mpz.S
Official Full Name
myelin protein zero S homeolog
Primary source
Xenbase:XB-GENE-876975
Locus tag
XELAEV_18042857mg
See related
EnsemblRapid:ENSXLAG00005026892 AllianceGenome:Xenbase:XB-GENE-876975
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
MPP; mpz
Summary
This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in the orthologous gene in human are associated with myelinating neuropathies. A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. A homeolog of this gene is found on chromosome 8L.[provided by RefSeq, Dec 2017]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See mpz.S in Genome Data Viewer
Location:
chromosome: 8S
Exon count:
6
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8S NC_054386.1 (100952418..100961056)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 8S NC_030739.1 (95941821..95950493)

Chromosome 8S - NC_054386.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 3 subunit F S homeolog Neighboring gene succinate dehydrogenase complex subunit C S homeolog Neighboring gene Purkinje cell protein 4 like 1 S homeolog Neighboring gene nuclear receptor subfamily 1 group I member 3 S homeolog

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Phylogenetically Conserved Sequences Around Myelin P0 Stop Codon are Essential for Translational Readthrough to Produce L-MPZ. Yamaguchi Y, et al. Neurochem Res, 2018 Jan. PMID 29081003
  2. L-MPZ, a novel isoform of myelin P0, is produced by stop codon readthrough. Yamaguchi Y, et al. J Biol Chem, 2012 May 18. PMID 22457349, Free PMC Article
  3. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by Xenbase

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
myelin protein P0 S homeolog
Names
Myelin peripheral protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001097887.2 → NP_001091356.2  myelin protein P0 S homeolog isoform MPZ precursor

    Status: REVIEWED

    Description
    Transcript Variant: This transcript (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (MPZ, also known as P0) results from translation termination at the upstream UAG stop codon, while the longer isoform (L-MPZ) results from UAG stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the shorter isoform (MPZ).
    Source sequence(s)
    BC129641, JAGEVR010000037
    UniProtKB/Swiss-Prot
    A2VD98
    UniProtKB/TrEMBL
    A0A974H6D8
    Related
    ENSXLAP00005079990.1, ENSXLAT00005081581.1
    Conserved Domains (2) summary
    cd05879
    Location:30 → 144
    Ig_P0; Immunoglobulin (Ig)-like domain of Protein zero (P0)
    pfam10570
    Location:182 → 245
    Myelin-PO_C; Myelin-PO cytoplasmic C-term p65 binding region

  2. NM_001358961.1 → NP_001345890.1  myelin protein P0 S homeolog isoform L-MPZ precursor

    Status: REVIEWED

    Description
    Transcript Variant: This transcript (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (MPZ, also known as P0) results from translation termination at the upstream UAG stop codon, while the longer isoform (L-MPZ) results from UAG stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the longer, C-terminally extended isoform (L-MPZ). As the UAG stop codon has been reported to specify several alternative amino acids (glutamine, tyrosine and leucine), its location in the longer isoform is denoted by an 'X'.
    Source sequence(s)
    BC129641, JAGEVR010000037
    UniProtKB/TrEMBL
    A0A8J0QFM7
    Conserved Domains (2) summary
    cd05879
    Location:30 → 144
    Ig_P0; Immunoglobulin (Ig)-like domain of Protein zero (P0)
    pfam10570
    Location:182 → 245
    Myelin-PO_C; Myelin-PO cytoplasmic C-term p65 binding region

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054386.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    100952418..100961056
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2VD98.1 GenPept UniProtKB/Swiss-Prot:A2VD98

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.