Pira12 paired-Ig-like receptor A12 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pira12provided by MGI
Official Full Name: paired-Ig-like receptor A12provided by MGI
Primary source: MGI:MGI:3709645
See related: Ensembl:ENSMUSG00000074417 AllianceGenome:MGI:3709645
Gene type: protein coding
RefSeq status: INFERRED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm14548
Summary: Predicted to enable several functions, including IgM binding activity; coreceptor activity; and inhibitory MHC class I receptor activity. Predicted to be involved in cytokine-mediated signaling pathway and immune response-regulating signaling pathway. Predicted to be part of Fc-epsilon receptor I complex. Predicted to be active in plasma membrane. Orthologous to several human genes including LILRA4 (leukocyte immunoglobulin like receptor A4); LILRA6 (leukocyte immunoglobulin like receptor A6); and LILRB3 (leukocyte immunoglobulin like receptor B3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in spleen adult (RPKM 29.6), mammary gland adult (RPKM 15.0) and 13 other tissues See more
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Genomic context

Location:: 7 A1; 7 2.24 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (3887200..3901158, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (3884201..3898159, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables IgM binding	ISO Inferred from Sequence Orthology more info
enables coreceptor activity	ISO Inferred from Sequence Orthology more info
enables inhibitory MHC class I receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response-regulating signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Fc-epsilon receptor I complex	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: paired-Ig-like receptor A12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001166672.2 → NP_001160144.1 paired-Ig-like receptor A12 isoform 1 precursor

Status: INFERRED

Source sequence(s)

AC161409

UniProtKB/TrEMBL

E9Q1Z6, Q3ZB55

Related

ENSMUSP00000070073.8, ENSMUST00000070639.8

Conserved Domains (2) summary

smart00410
Location:529 → 617

IG_like; Immunoglobulin like

cl11960
Location:225 → 315

Ig; Immunoglobulin domain
NM_001384210.1 → NP_001371139.1 paired-Ig-like receptor A12 isoform 2 precursor

Status: INFERRED

Source sequence(s)

AC161409

UniProtKB/TrEMBL

O70434

Conserved Domains (3) summary

cd00096
Location:124 → 128

Ig; Ig strand A [structural motif]

cd16843
Location:225 → 314

IgC2_D1_D2_LILR_KIR_like; Immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors, Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains

cl11960
Location:123 → 219

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

3887200..3901158 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006539428.4 → XP_006539491.1 paired-Ig-like receptor A12 isoform X1

UniProtKB/TrEMBL

O70434

Conserved Domains (1) summary

cl11960
Location:225 → 315

Ig; Immunoglobulin domain
XM_006539430.2 → XP_006539493.1 paired-Ig-like receptor A12 isoform X3

Conserved Domains (1) summary

cl11960
Location:27 → 118

Ig; Immunoglobulin domain
XM_006539429.5 → XP_006539492.1 paired-Ig-like receptor A12 isoform X2

UniProtKB/TrEMBL

O55002

Conserved Domains (1) summary

cl11960
Location:225 → 315

Ig; Immunoglobulin domain