Amy2a1 amylase 2a1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Amy2a1provided by MGI
Official Full Name: amylase 2a1provided by MGI
Primary source: MGI:MGI:104548
See related: AllianceGenome:MGI:104548
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PA; Amy2; Amy2a; Amy2-1; mAmy2-6
Summary: Predicted to enable alpha-amylase activity; calcium ion binding activity; and chloride ion binding activity. Predicted to be involved in carbohydrate metabolic process. Predicted to be active in extracellular space. Orthologous to several human genes including AMY2A (amylase alpha 2A) and AMY2B (amylase alpha 2B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in small intestine adult (RPKM 1029.3), spleen adult (RPKM 572.4) and 1 other tissue See more
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Genomic context

Location:: 3 F3; 3 49.35 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (113314932..113325939, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (113528095..113532428, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Generation of a new transgenic mouse that should be useful to target endoderm at early stages, without affecting the liver or ventral pancreas before embryonic day E12.5.
Title: An amylase/Cre transgene marks the whole endoderm but the primordia of liver and ventral pancreas.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Amy2 (e-PCR), detects polymorphism
- UniSTS:141077

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alpha-amylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-amylase activity	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables chloride ion binding	ISO Inferred from Sequence Orthology more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in carbohydrate metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: amylase 2a1

Names: 1,4-alpha-D-glucan glucanohydrolase; Pancreatic alpha-amylase; amylase 2-1, pancreatic; amylase 2a1, pancreatic

NP_001398423.1

EC 3.2.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.