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Hsd3b8 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 8 [ Mus musculus (house mouse) ]

Gene ID: 100043456, updated on 27-Nov-2024

Summary

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Official Symbol
Hsd3b8provided by MGI
Official Full Name
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 8provided by MGI
Primary source
MGI:MGI:3711284
See related
Ensembl:ENSMUSG00000095388 AllianceGenome:MGI:3711284
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hsd3b4; Gm10681
Summary
Predicted to enable 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity; steroid binding activity; and steroid delta-isomerase activity. Predicted to be involved in progesterone metabolic process; regulation of steroid biosynthetic process; and steroid biosynthetic process. Predicted to be located in several cellular components, including intercellular bridge; mitochondrial envelope; and nucleolus. Is expressed in several structures, including alimentary system; eye; heart; integumental system; and nervous system. Human ortholog(s) of this gene implicated in hypertension and hypospadias. Orthologous to human HSD3B1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1) and HSD3B2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward kidney adult (RPKM 519.4) See more
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Genomic context

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See Hsd3b8 in Genome Data Viewer
Location:
3 F2.2; 3 42.8 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (98459858..98471366, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (98552542..98564050, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 697 Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 4 Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 pseudogene Neighboring gene predicted gene 5853 Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of multiple forms of 3 beta-hydroxysteroid dehydrogenase in the mouse liver during fetal and postnatal development. Park CH, et al. Mol Cell Endocrinol, 1996 Feb 5. PMID 8647315
  2. Isolation and characterization of several members of the murine Hsd3b gene family. Clarke TR, et al. DNA Cell Biol, 1996 May. PMID 8924213
  3. The genes encoding gonadal and nongonadal forms of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase are closely linked on mouse chromosome 3. Bain PA, et al. Genomics, 1993 Apr. PMID 8486361
  4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
  
enables steroid binding ISO
Inferred from Sequence Orthology
more info
  
enables steroid delta-isomerase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in progesterone metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of steroid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in steroid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase-like
Names
3 beta-hydroxysteroid dehydrogenase type 4
3 beta-hydroxysteroid dehydrogenase type IV
3-beta-HSD IV
3-beta-hydroxy-5-ene steroid dehydrogenase
NADPH-dependent 3-beta-hydroxy-Delta(5)-steroid dehydrogenase
Progesterone reductase
NP_001257358.1
XP_006500871.1
XP_017174900.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270429.1 → NP_001257358.1  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase-like

    See identical proteins and their annotated locations for NP_001257358.1

    Status: VALIDATED

    Source sequence(s)
    AC139379
    Consensus CDS
    CCDS57247.1
    UniProtKB/Swiss-Prot
    Q61767
    UniProtKB/TrEMBL
    A0A087WRE2, Q3UIU9
    Related
    ENSMUSP00000055886.6, ENSMUST00000058728.10
    Conserved Domains (1) summary
    cl21454
    Location:5 → 357
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    98459858..98471366 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319411.1 → XP_017174900.1  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase-like isoform X2

    UniProtKB/Swiss-Prot
    Q61767
    UniProtKB/TrEMBL
    A0A087WRE2, Q3UIU9
    Conserved Domains (1) summary
    cl21454
    Location:5 → 357
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. XM_006500808.2 → XP_006500871.1  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase-like isoform X1

    See identical proteins and their annotated locations for XP_006500871.1

    Conserved Domains (1) summary
    cl21454
    Location:31 → 383
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein Strain
Heading Accession and Version

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