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Amy2a4 amylase 2a4 [ Mus musculus (house mouse) ]

Gene ID: 100043684, updated on 27-Nov-2024

Summary

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Official Symbol
Amy2a4provided by MGI
Official Full Name
amylase 2a4provided by MGI
Primary source
MGI:MGI:3711258
See related
Ensembl:ENSMUSG00000096770 AllianceGenome:MGI:3711258
Gene type
protein coding
RefSeq status
INFERRED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PA; Amy2; Amy2a; mAmy2-3
Summary
Predicted to enable alpha-amylase activity; calcium ion binding activity; and chloride ion binding activity. Predicted to be located in extracellular space. Orthologous to several human genes including AMY2A (amylase alpha 2A) and AMY2B (amylase alpha 2B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in spleen adult (RPKM 523.5), small intestine adult (RPKM 403.8) and 2 other tissues See more
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Genomic context

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See Amy2a4 in Genome Data Viewer
Location:
3 F3; 3 49.35 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (113187153..113198765, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (113279837..113291449, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene amylase 2, pseudogene 1 Neighboring gene amylase 2a5 Neighboring gene amylase 2a3 Neighboring gene amylase 2a2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tissue-specific expression of mouse-alpha-amylase genes: nucleotide sequence of isoenzyme mRNAs from pancreas and salivary gland. Hagenbüchle O, et al. Cell, 1980 Aug. PMID 6157477
  2. Comparative genomic analysis of the mouse and rat amylase multigene family. Sugino H. FEBS Lett, 2007 Feb 6. PMID 17223109
  3. The mouse alpha-amylase multigene family. Sequence organization of members expressed in the pancreas, salivary gland and liver. Schibler U, et al. J Mol Biol, 1982 Mar 5. PMID 6176715
  4. Termination of transcription in the mouse alpha-amylase gene Amy-2a occurs at multiple sites downstream of the polyadenylation site. Hagenbüchle O, et al. Cell, 1984 Oct. PMID 6091898
  5. Expression of mouse Amy-2a alpha-amylase genes is regulated by strong pancreas-specific promoters. Hagenbüchle O, et al. J Mol Biol, 1985 Sep 20. PMID 3877171

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-amylase activity ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables chloride ion binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
amylase 2a4
Names
1,4-alpha-D-glucan glucanohydrolase
Pancreatic alpha-amylase
amylase 2a4, pancreatic
NP_001153622.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160150.1 → NP_001153622.1  amylase 2a4 precursor

    See identical proteins and their annotated locations for NP_001153622.1

    Status: INFERRED

    Source sequence(s)
    AC161580
    Consensus CDS
    CCDS51054.1
    UniProtKB/Swiss-Prot
    P00688, Q4VBW6, Q61295, Q61296, Q64301
    Related
    ENSMUSP00000137025.2, ENSMUST00000179568.3
    Conserved Domains (3) summary
    cd11317
    Location:25 → 413
    AmyAc_bac_euk_AmyA; Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)
    smart00632
    Location:420 → 507
    Aamy_C; Aamy_C domain
    COG0366
    Location:46 → 344
    AmyA; Glycosidase [Carbohydrate transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    113187153..113198765 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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