Klrb1 killer cell lectin-like receptor subfamily B member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klrb1provided by MGI
Official Full Name: killer cell lectin-like receptor subfamily B member 1provided by MGI
Primary source: MGI:MGI:96877
See related: Ensembl:ENSMUSG00000079299 AllianceGenome:MGI:96877
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ly55; Klrb6; Ly-55; Gm4696; Klrb1g; Nkrp1g; NKR-P1G; Nkrp-1e; 4930431A04Rik
Summary: Enables signaling receptor activity. Predicted to be involved in regulation of natural killer cell mediated cytotoxicity. Predicted to be located in membrane. Predicted to be active in cell surface and plasma membrane. Orthologous to human KLRB1 (killer cell lectin like receptor B1). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Restricted expression toward testis adult (RPKM 6.8) See more
Orthologs: human all
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Genomic context

Location:: 6 F3; 6 63.08 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (128683056..128701293, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (128706093..128724330, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

in the spleen, Nkrp1g is selectively expressed by a subset of Natural Killer Cells, thereby potentially allowing for an inhibitory engagement with Clr-g-expressing activated Dendritic Cells during immune responses.
Title: Select Clr-g Expression on Activated Dendritic Cells Facilitates Cognate Interaction with a Minor Subset of Splenic NK Cells Expressing the Inhibitory Nkrp1g Receptor.
LLT1 and CD161 have roles in modulating immune responses to pathogens; and interferon-gamma contributes to modulate immune responses
Title: Induction of lectin-like transcript 1 (LLT1) protein cell surface expression by pathogens and interferon-γ contributes to modulate immune responses.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of natural killer cell mediated cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: killer cell lectin-like receptor subfamily B member 1

Names: immunoreceptor NKR-P1G; killer cell lectin-like receptor subfamily A member 1 complex; killer cell lectin-like receptor subfamily B member 1 complex; killer cell lectin-like receptor subfamily B member 1G; lectin-like transmembrane protein Nkrp1g; lymphocyte antigen 55; natural killer cell surface protein NKR-P1G; natural killer lectin-like receptor 1E; natural killer lectin-like receptor protein 1 e

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001099918.2 → NP_001093388.1 killer cell lectin-like receptor subfamily B member 1

See identical proteins and their annotated locations for NP_001093388.1

Status: VALIDATED

Source sequence(s)

AC132352

Consensus CDS

CCDS39653.1

UniProtKB/Swiss-Prot

Q0ZUP1, Q1A4F6

UniProtKB/TrEMBL

A0A1U9W1A8, F2YRQ5

Related

ENSMUSP00000107738.3, ENSMUST00000112110.4

Conserved Domains (1) summary

cd03593
Location:91 → 209

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

128683056..128701293 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017321281.1 → XP_017176770.1 killer cell lectin-like receptor subfamily B member 1 isoform X1

UniProtKB/TrEMBL

F2YRQ5

Conserved Domains (1) summary

cd03593
Location:120 → 238

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)