Mir574 microRNA 574 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mir574provided by MGI
Official Full Name: microRNA 574provided by MGI
Primary source: MGI:MGI:3718549
See related: Ensembl:ENSMUSG00000077042 miRBase:MI0005518; AllianceGenome:MGI:3718549
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mirn574; mir-574; mmu-mir-574
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: 5 C3.1; 5 33.55 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (65127661..65127738)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (64970318..64970395)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A positive feedback loop between miR-574-3p and HIF-1alpha in promoting angiogenesis under hypoxia.
Title: A positive feedback loop between miR-574-3p and HIF-1α in promoting angiogenesis under hypoxia.
MicroRNA-574-5p targeting HOXC6 expression inhibits the hepatocyte lipid uptake to alleviate non-alcoholic fatty liver disease.
Title: MicroRNA-574-5p targeting HOXC6 expression inhibits the hepatocyte lipid uptake to alleviate non-alcoholic fatty liver disease.
Serum-derived miR-574-5p-containing exosomes contribute to liver fibrosis by activating hepatic stellate cells.
Title: Serum-derived miR-574-5p-containing exosomes contribute to liver fibrosis by activating hepatic stellate cells.
MicroRNA-574 regulates FAM210A expression and influences pathological cardiac remodeling.
Title: MicroRNA-574 regulates FAM210A expression and influences pathological cardiac remodeling.
Cryptotanshinone interferes with chondrocyte apoptosis in osteoarthritis by inhibiting the expression of miR5745p.
Title: Cryptotanshinone interferes with chondrocyte apoptosis in osteoarthritis by inhibiting the expression of miR‑574‑5p.
MicroRNA-574-5p Attenuates Acute Respiratory Distress Syndrome by Targeting HMGB1.
Title: MicroRNA-574-5p Attenuates Acute Respiratory Distress Syndrome by Targeting HMGB1.
In the Fbn1(C1041G/+) mouse model, miR-574-5p was down-regulated in aortic tissue compared to wild-type (p < 0.05), and up-regulated in plasma extracellular vesicles from Fbn1(C1041G/+) mice compared to wild-type mice (p < 0.05).
Title: MiR-574-5p: A Circulating Marker of Thoracic Aortic Aneurysm.
Data show that APP regulates the expression of microRNAs in the cortex and in neural progenitors, specifically repressing miR-574-5p.
Title: Amyloid precursor protein regulates neurogenesis by antagonizing miR-574-5p in the developing cerebral cortex.
MicroRNA-574-5p has a critical role in TLR9 signaling enhanced tumor progression via down-regulating checkpoint suppressor 1
Title: MicroRNA-574-5p was pivotal for TLR9 signaling enhanced tumor progression via down-regulating checkpoint suppressor 1 in human lung cancer.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to estrogen stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within regulation of neural precursor cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to oxygen levels	IDA Inferred from Direct Assay more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.