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irgf1 immunity-related GTPase family, f1 [ Danio rerio (zebrafish) ]

Gene ID: 100137101, updated on 5-Jan-2025

Summary

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Official Symbol
irgf1provided by ZNC
Official Full Name
immunity-related GTPase family, f1provided by ZNC
Primary source
ZFIN:ZDB-GENE-051212-5
See related
Ensembl:ENSDARG00000070774 AllianceGenome:ZFIN:ZDB-GENE-051212-5
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable GTP binding activity and GTPase activity. Predicted to be located in membrane. Orthologous to human IRGC (immunity related GTPase cinema). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See irgf1 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (23296613..23300048)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (23712290..23715725)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene transfer RNA proline (anticodon AGG) Neighboring gene growth factor receptor-bound protein 10a Neighboring gene si:dkey-79i2.4 Neighboring gene uncharacterized LOC137488438 Neighboring gene uncharacterized LOC108180103

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. DNA hypomethylation causes bile duct defects in zebrafish and is a distinguishing feature of infantile biliary atresia. Matthews RP, et al. Hepatology, 2011 Mar. PMID 21319190, Free PMC Article
  2. Mycobacterial CpsA activates type I IFN signaling in macrophages via cGAS-mediated pathway. Ding Y, et al. iScience, 2024 May 17. PMID 38766355, Free PMC Article
  3. The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage. Bekpen C, et al. Genome Biol, 2005. PMID 16277747, Free PMC Article
  4. In vivo analysis of Ifn-γ1 and Ifn-γ2 signaling in zebrafish. Aggad D, et al. J Immunol, 2010 Dec 1. PMID 21048110
  5. The role of gamma interferon in innate immunity in the zebrafish embryo. Sieger D, et al. Dis Model Mech, 2009 Nov-Dec. PMID 19779068

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
immunity-related GTPase family, f1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320423.1 → NP_001307352.1  immunity-related GTPase family, f1

    Status: VALIDATED

    Source sequence(s)
    BC155604, CR384077, CT009671, EH505681
    UniProtKB/TrEMBL
    A0A8M1P8B8, A5WVI1, A9JRC3
    Related
    ENSDARP00000116407.1, ENSDART00000134567.3
    Conserved Domains (1) summary
    pfam05049
    Location:11 → 390
    IIGP; Interferon-inducible GTPase (IIGP)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    23296613..23300048
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021467975.2 → XP_021323650.1  immunity-related GTPase family, f1 isoform X1

    UniProtKB/TrEMBL
    A0A8M1P8B8, A5WVI1, A9JRC3
    Conserved Domains (1) summary
    pfam05049
    Location:11 → 390
    IIGP; Interferon-inducible GTPase (IIGP)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001114698.1: Suppressed sequence

    Description
    NM_001114698.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version

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