PRKAR2A protein kinase cAMP-dependent type II regulatory subunit alpha [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: PRKAR2Aprovided by VGNC
Official Full Name: protein kinase cAMP-dependent type II regulatory subunit alphaprovided by VGNC
Primary source: VGNC:VGNC:33325
See related: BGD:BT28621; Ensembl:ENSBTAG00000014205
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	22	NC_037349.1 (51085601..51155609)

Chromosome 22 - NC_037349.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

angle X-ray scattering studies indicate RIalpha, RIIalpha, and RIIbeta homodimers differ markedly in overall shape despite extensive sequence homology and similar molecular masses;cAMP binding does not cause large conformational changes(Prkar1a, Prkar2a)
Title: Conformational differences among solution structures of the type Ialpha, IIalpha and IIbeta protein kinase A regulatory subunit homodimers: role of the linker regions.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cAMP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables cAMP-dependent protein kinase inhibitor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein kinase A catalytic subunit binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of cAMP-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of cAMP-dependent protein kinase complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: cAMP-dependent protein kinase type II-alpha regulatory subunit

Names: protein kinase, cAMP-dependent, regulatory, type 2, alpha

NP_001178296.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191367.2 → NP_001178296.1 cAMP-dependent protein kinase type II-alpha regulatory subunit

Status: PROVISIONAL

Source sequence(s)

NKLS02000022

UniProtKB/Swiss-Prot

P00515

UniProtKB/TrEMBL

A0AAF6YZS2

Related

ENSBTAP00000018886.6, ENSBTAT00000018886.7

Conserved Domains (2) summary

cd12103
Location:4 → 44

DD_RIIalpha_PKA; Dimerization/Docking domain of the Type II alpha Regulatory subunit of cAMP-dependent protein kinase

cd00038
Location:258 → 379

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...