U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

rsph4a radial spoke head component 4A [ Danio rerio (zebrafish) ]

Gene ID: 100148286, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
rsph4aprovided by ZNC
Official Full Name
radial spoke head component 4Aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-7437
See related
Ensembl:ENSDARG00000067606 AllianceGenome:ZFIN:ZDB-GENE-030131-7437
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
rshl3; rsph6a; wu:fj17d05
Summary
Predicted to be involved in axoneme assembly and cilium movement. Predicted to act upstream of or within cilium assembly and cilium movement involved in cell motility. Predicted to be located in cilium; cytoplasm; and cytoskeleton. Predicted to be part of radial spoke. Predicted to be active in axoneme. Is expressed in midbrain; otic placode; pronephric duct; and spinal cord neural rod. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 11. Orthologous to several human genes including RSPH4A (radial spoke head component 4A). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See rsph4a in Genome Data Viewer
Location:
chromosome: 5
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (61919224..61930917)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (61256479..61268123)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene interferon-induced protein with tetratricopeptide repeats 5 Neighboring gene symplekin Neighboring gene N-ethylmaleimide-sensitive factor attachment protein, alpha a Neighboring gene zinc finger BED-type containing 4-like 2 Neighboring gene zinc finger protein 541

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Novel roles for the radial spoke head protein 9 in neural and neurosensory cilia. Sedykh I, et al. Sci Rep, 2016 Sep 30. PMID 27687975, Free PMC Article
  2. Radial spoke proteins regulate otolith formation during early zebrafish development. Han X, et al. FASEB J, 2018 Jul. PMID 29475374
  3. Systematic discovery of novel ciliary genes through functional genomics in the zebrafish. Choksi SP, et al. Development, 2014 Sep. PMID 25139857, Free PMC Article
  4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. rsph4a is essential for ciliary motility and otolith formation during early zebrafish development.
    Title: Radial spoke proteins regulate otolith formation during early zebrafish development.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in axoneme assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cilium assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium movement IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cilium movement involved in cell motility IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of radial spoke IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
radial spoke head protein 4 homolog A
Names
radial spoke head 4 homolog A
radial spoke head 6 homolog A
radial spokehead-like 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    61919224..61930917
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001923735.7 → XP_001923770.1  radial spoke head protein 4 homolog A

    UniProtKB/TrEMBL
    A0A8M1QHY3, A2CET1
    Related
    ENSDARP00000088110.4, ENSDART00000097340.5
    Conserved Domains (1) summary
    pfam04712
    Location:18 → 503
    Radial_spoke; Radial spokehead-like protein
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.