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si sucrase-isomaltase [ Danio rerio (zebrafish) ]

Gene ID: 100148922, updated on 2-Nov-2024

Summary

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Official Symbol
siprovided by ZNC
Official Full Name
sucrase-isomaltaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-4622
See related
AllianceGenome:ZFIN:ZDB-GENE-030131-4622
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
mgam; fd42f04; fd44a09; wu:fd42f04; wu:fd44a09
Summary
Predicted to enable alpha-glucosidase activity and carbohydrate binding activity. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be located in apical plasma membrane. Human ortholog(s) of this gene implicated in congenital sucrase-isomaltase deficiency. Orthologous to several human genes including SI (sucrase-isomaltase). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: partial on reference assembly
Orthologs
all
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Genomic context

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Location:
chromosome: 18
Exon count:
47
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (1761556..1929025)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (2028736..2117690)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488243 Neighboring gene SLIT and NTRK-like family, member 3a Neighboring gene protein unc-13 homolog C-like Neighboring gene protogenin homolog a (Gallus gallus)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Cross-generational feeding of Bt (Bacillus thuringiensis)-maize to zebrafish (Danio rerio) showed no adverse effects on the parental or offspring generations. Sanden M, et al. Br J Nutr, 2013 Dec. PMID 23768244
  2. Glucose overload in yolk has little effect on the long-term modulation of carbohydrate metabolic genes in zebrafish (Danio rerio). Rocha F, et al. J Exp Biol, 2014 Apr 1. PMID 24363414
  3. Exogenous maltose enhances Zebrafish immunity to levofloxacin-resistant Vibrio alginolyticus. Jiang M, et al. Microb Biotechnol, 2020 Jul. PMID 32364684, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables alpha-glucosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
maltase-glucoamylase, intestinal; sucrase-isomaltase, intestinal
Names
maltase-glucoamylase (alpha-glucosidase)
sucrase-isomaltase (alpha-glucosidase)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    1761556..1929025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017351979.3 → XP_017207468.1  sucrase-isomaltase, intestinal

    UniProtKB/TrEMBL
    A0A8M6Z206
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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