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Gpn2 GPN-loop GTPase 2 [ Mus musculus (house mouse) ]

Gene ID: 100210, updated on 27-Nov-2024

Summary

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Official Symbol
Gpn2provided by MGI
Official Full Name
GPN-loop GTPase 2provided by MGI
Primary source
MGI:MGI:2140368
See related
Ensembl:ENSMUSG00000028848 AllianceGenome:MGI:2140368
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Atpbd1b
Summary
Predicted to enable GTPase activity. Is expressed in collecting duct; liver; renal calyx; and ureter. Orthologous to human GPN2 (GPN-loop GTPase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 24.7), duodenum adult (RPKM 20.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Gpn2 in Genome Data Viewer
Location:
4 D2.3; 4 66.25 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (133311684..133319046)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (133584373..133591735)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene nuclear receptor subfamily 0, group B, member 2 Neighboring gene G patch domain containing 3 Neighboring gene predicted gene, 42324 Neighboring gene STARR-seq mESC enhancer starr_11639 Neighboring gene stratifin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article
  2. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
  3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GPN-loop GTPase 2
Names
ATP binding domain 1 family, member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290742.1 → NP_001277671.1  GPN-loop GTPase 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AL627228
    Consensus CDS
    CCDS71484.1
    UniProtKB/TrEMBL
    A2A9F7
    Related
    ENSMUSP00000101519.2, ENSMUST00000105899.2
    Conserved Domains (2) summary
    COG1100
    Location:13 → 159
    Gem1; GTPase SAR1 family domain [General function prediction only]
    pfam03029
    Location:14 → 238
    ATP_bind_1; Conserved hypothetical ATP binding protein

  2. NM_133884.2 → NP_598645.2  GPN-loop GTPase 2 isoform 1

    See identical proteins and their annotated locations for NP_598645.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BQ552936, CN721622, CO798620
    Consensus CDS
    CCDS18753.1
    UniProtKB/Swiss-Prot
    A2A9E9, Q8VEJ1
    Related
    ENSMUSP00000030661.8, ENSMUST00000030661.14
    Conserved Domains (2) summary
    COG1100
    Location:13 → 182
    Gem1; GTPase SAR1 family domain [General function prediction only]
    pfam03029
    Location:14 → 261
    ATP_bind_1; Conserved hypothetical ATP binding protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    133311684..133319046
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VEJ1.2 GenPept UniProtKB/Swiss-Prot:Q8VEJ1

Gene LinkOut

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