U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cox16 cytochrome c oxidase assembly factor COX16 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100302447, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Cox16provided by RGD
Official Full Name
cytochrome c oxidase assembly factor COX16provided by RGD
Primary source
RGD:2311610
See related
EnsemblRapid:ENSRNOG00000047115 AllianceGenome:RGD:2311610
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in mitochondrial cytochrome c oxidase assembly. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 22. Orthologous to human COX16 (cytochrome c oxidase assembly factor COX16). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 163.8), Adrenal (RPKM 101.7) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Cox16 in Genome Data Viewer
Location:
6q24
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (106745424..106912523, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (101162231..101181277, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (105195387..105214366, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene SPARC related modular calcium binding 1 Neighboring gene uncharacterized LOC120103570 Neighboring gene uncharacterized LOC120103571 Neighboring gene uncharacterized LOC134479222 Neighboring gene solute carrier family 8 member A3 Neighboring gene a disintegrin and metallopeptidase domain 4-like 1 Neighboring gene uncharacterized LOC134479224 Neighboring gene a disintegrin and metalloprotease domain 4 Neighboring gene synaptojanin 2 binding protein Neighboring gene uncharacterized LOC103690066

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. COX16 promotes COX2 metallation and assembly during respiratory complex IV biogenesis. Aich A, et al. Elife, 2018 Jan 30. PMID 29381136, Free PMC Article
  2. COX16 is required for assembly of cytochrome c oxidase in human cells and is involved in copper delivery to COX2. Cerqua C, et al. Biochim Biophys Acta Bioenerg, 2018 Apr. PMID 29355485
  3. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in mitochondrial cytochrome c oxidase assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial cytochrome c oxidase assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
COX16 cytochrome c oxidase assembly homolog
Names
COX16, cytochrome c oxidase assembly homolog
cytochrome c oxidase assembly protein 16

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163153.1 → NP_001156625.1  COX16 cytochrome c oxidase assembly homolog

    See identical proteins and their annotated locations for NP_001156625.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A6JDM6
    Related
    ENSRNOP00000008954.5, ENSRNOT00000008954.7
    Conserved Domains (1) summary
    pfam14138
    Location:16 → 88
    COX16; Cytochrome c oxidase assembly protein COX16

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    106745424..106912523 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063261363.1 → XP_063117433.1  COX16 cytochrome c oxidase assembly homolog isoform X2

    UniProtKB/TrEMBL
    D3Z8B0

  2. XM_006240298.4 → XP_006240360.1  COX16 cytochrome c oxidase assembly homolog isoform X1

    Conserved Domains (1) summary
    pfam14138
    Location:16 → 68
    COX16; Cytochrome c oxidase assembly protein COX16
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.