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Fcgbp Fc gamma binding protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 100303643, updated on 4-Jan-2025

Summary

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Official Symbol
Fcgbpprovided by RGD
Official Full Name
Fc gamma binding proteinprovided by RGD
Primary source
RGD:2313189
See related
EnsemblRapid:ENSRNOG00000019129 AllianceGenome:RGD:2313189
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be active in extracellular matrix and extracellular space. Orthologous to human FCGBP (Fc gamma binding protein). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 33.3), Uterus (RPKM 31.1) and 7 other tissues See more
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Genomic context

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See Fcgbp in Genome Data Viewer
Location:
1q21
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (92502461..92540658)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (83374979..83413082)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (85003280..85046840)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene proteasome 26S subunit, ATPase 4 Neighboring gene U2 spliceosomal RNA Neighboring gene RNA, U6 small nuclear 105 Neighboring gene Fc fragment of IgG binding protein-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The rat IgGFcγBP and Muc2 C-terminal domains and TFF3 in two intestinal mucus layers bind together by covalent interaction. Yu H, et al. PLoS One, 2011. PMID 21629776, Free PMC Article
  2. Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein. Johansson ME, et al. J Proteome Res, 2009 Jul. PMID 19432394
  3. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Fc fragment of IgG binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164657.3 → NP_001158129.3  Fc fragment of IgG binding protein precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I5ZQD3, D3ZJF8
    Related
    ENSRNOP00000053950.5, ENSRNOT00000057122.6
    Conserved Domains (7) summary
    smart00216
    Location:2024 → 2180
    VWD; von Willebrand factor (vWF) type D domain
    smart00832
    Location:2222 → 2296
    C8; This domain contains 8 conserved cysteine residues
    cl17735
    Location:775 → 829
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:56 → 210
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:1917 → 1970
    TIL; Trypsin Inhibitor like cysteine rich domain
    cd19941
    Location:1530 → 1584
    TIL; trypsin inhibitor-like cysteine rich domain
    cl02516
    Location:2406 → 2560
    VWD; von Willebrand factor type D domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    92502461..92540658
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108772.2 → XP_038964700.1  Fc fragment of IgG binding protein isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZQD3, D3ZJF8
    Conserved Domains (7) summary
    smart00216
    Location:2024 → 2180
    VWD; von Willebrand factor (vWF) type D domain
    smart00832
    Location:2222 → 2296
    C8; This domain contains 8 conserved cysteine residues
    cl17735
    Location:775 → 829
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:56 → 210
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:1917 → 1970
    TIL; Trypsin Inhibitor like cysteine rich domain
    cd19941
    Location:1530 → 1584
    TIL; trypsin inhibitor-like cysteine rich domain
    cl02516
    Location:2406 → 2560
    VWD; von Willebrand factor type D domain
Nucleotide Protein Strain
Heading Accession and Version

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