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Snrpe small nuclear ribonucleoprotein polypeptide E [ Rattus norvegicus (Norway rat) ]

Gene ID: 100360682, updated on 27-Nov-2024

Summary

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Official Symbol
Snrpeprovided by RGD
Official Full Name
small nuclear ribonucleoprotein polypeptide Eprovided by RGD
Primary source
RGD:2321675
See related
EnsemblRapid:ENSRNOG00000067587 AllianceGenome:RGD:2321675
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables U1 snRNP binding activity. Predicted to be involved in spliceosomal snRNP assembly. Part of U1 snRNP. Used to study lupus nephritis. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; hypotrichosis 1; hypotrichosis 11; and lupus nephritis. Orthologous to human SNRPE (small nuclear ribonucleoprotein polypeptide E). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 744.5), Spleen (RPKM 470.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Snrpe in Genome Data Viewer
Location:
13q13
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (47596324..47609390, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (45050986..45057231, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (50252707..50258951)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene SRY-box transcription factor 13 Neighboring gene uncharacterized LOC103692077 Neighboring gene uncharacterized LOC134481497 Neighboring gene zinc finger CCCH-type containing 11A Neighboring gene uncharacterized LOC108352533 Neighboring gene NADH:ubiquinone oxidoreductase subunit B10, pseudogene 1 Neighboring gene zinc finger, BED-type containing 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Customized oligonucleotide microarray gene expression-based classification of neuroblastoma patients outperforms current clinical risk stratification. Oberthuer A, et al. J Clin Oncol, 2006 Nov 1. PMID 17075126
  2. SNRPE is involved in cell proliferation and progression of high-grade prostate cancer through the regulation of androgen receptor expression. Anchi T, et al. Oncol Lett, 2012 Feb. PMID 22740892, Free PMC Article
  3. Genome-wide copy number analyses identified novel cancer genes in hepatocellular carcinoma. Jia D, et al. Hepatology, 2011 Oct. PMID 21688285
  4. Intravenous injection of a D1 protein of the Smith proteins postpones murine lupus and induces type 1 regulatory T cells. Riemekasten G, et al. J Immunol, 2004 Nov 1. PMID 15494537
  5. Mutations in SNRPE, which encodes a core protein of the spliceosome, cause autosomal-dominant hypotrichosis simplex. Pasternack SM, et al. Am J Hum Genet, 2013 Jan 10. PMID 23246290, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables U1 snRNP binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in spliceosomal snRNP assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spliceosomal snRNP assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of SMN-Sm protein complex ISO
Inferred from Sequence Orthology
more info
  
part_of U1 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U1 snRNP IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U1 snRNP ISO
Inferred from Sequence Orthology
more info
  
part_of U12-type spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  
part_of U2 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2-type catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of U2-type precatalytic spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of U2-type spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  
part_of U4 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U4 snRNP ISO
Inferred from Sequence Orthology
more info
  
part_of U4/U6 x U5 tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U4/U6 x U5 tri-snRNP complex ISO
Inferred from Sequence Orthology
more info
  
part_of U5 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U7 snRNP ISO
Inferred from Sequence Orthology
more info
  
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of methylosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of pICln-Sm protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of pICln-Sm protein complex ISO
Inferred from Sequence Orthology
more info
  
part_of precatalytic spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  
part_of telomerase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
small nuclear ribonucleoprotein E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271237.1 → NP_001258166.1  small nuclear ribonucleoprotein E

    See identical proteins and their annotated locations for NP_001258166.1

    Status: VALIDATED

    Source sequence(s)
    FQ211122
    UniProtKB/TrEMBL
    A6IC83, D3ZSP1
    Related
    ENSRNOP00000083123.2, ENSRNOT00000118359.2
    Conserved Domains (1) summary
    cd01718
    Location:11 → 89
    Sm_E; Sm protein E

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    47596324..47609390 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063271937.1 → XP_063128007.1  small nuclear ribonucleoprotein E isoform X2

    UniProtKB/TrEMBL
    A6IC83

  2. XM_063271939.1 → XP_063128009.1  small nuclear ribonucleoprotein E isoform X3

    UniProtKB/TrEMBL
    A0A8I6AA88

  3. XM_063271938.1 → XP_063128008.1  small nuclear ribonucleoprotein E isoform X3

    UniProtKB/TrEMBL
    A0A8I6AA88

  4. XM_063271941.1 → XP_063128011.1  small nuclear ribonucleoprotein E isoform X5

  5. XM_063271936.1 → XP_063128006.1  small nuclear ribonucleoprotein E isoform X1

    Related
    ENSRNOP00000088685.2, ENSRNOT00000093917.2

  6. XM_063271942.1 → XP_063128012.1  small nuclear ribonucleoprotein E isoform X6

  7. XM_063271943.1 → XP_063128013.1  small nuclear ribonucleoprotein E isoform X6

  8. XM_063271940.1 → XP_063128010.1  small nuclear ribonucleoprotein E isoform X4

Nucleotide Protein Strain
Heading Accession and Version

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