U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cfhr2l1 complement factor H-related 2-like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100361907, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Cfhr2l1provided by RGD
Official Full Name
complement factor H-related 2-like 1provided by RGD
Primary source
RGD:2319172
See related
EnsemblRapid:ENSRNOG00000052604 AllianceGenome:RGD:2319172
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable complement component C3b binding activity. Predicted to be involved in complement activation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in age related macular degeneration 1 and atypical hemolytic-uremic syndrome. Orthologous to several human genes including CFHR4 (complement factor H related 4). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward (RPKM 2284.1) See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Cfhr2l1 in Genome Data Viewer
Location:
13q13
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (53813350..53847482, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (51262631..51296767, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (56729910..56764060, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene coagulation factor XIII B chain Neighboring gene complement factor H-related 2 Neighboring gene complement factor H-like Neighboring gene complement factor H-related 1, pseudogene 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables complement component C3b binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in complement activation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
complement factor H-related protein B
Names
Cfh protein-like
complement factor H-like
complement factor H-related protein 2-like
complement factor H-related protein 3-like

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001402196.1 → NP_001389125.1  complement factor H-related protein B precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A0G2JYC4, Q5FVP9
    Related
    ENSRNOP00000070600.2, ENSRNOT00000087916.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    53813350..53847482 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008769581.4 → XP_008767803.2  complement factor H-related protein B isoform X2

    Conserved Domains (1) summary
    PHA02927
    Location:35 → 267
    PHA02927; secreted complement-binding protein; Provisional

  2. XM_039091343.2 → XP_038947271.1  complement factor H-related protein B isoform X3

    Conserved Domains (1) summary
    PHA02927
    Location:52 → 253
    PHA02927; secreted complement-binding protein; Provisional

  3. XM_039091342.2 → XP_038947270.1  complement factor H-related protein B isoform X1

    Conserved Domains (1) summary
    PHA02927
    Location:98 → 312
    PHA02927; secreted complement-binding protein; Provisional
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials