U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Btbd8 BTB domain containing 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100364240, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Btbd8provided by RGD
Official Full Name
BTB domain containing 8provided by RGD
Primary source
RGD:2321418
See related
EnsemblRapid:ENSRNOG00000023446 AllianceGenome:RGD:2321418
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in synaptic vesicle budding from endosome and synaptic vesicle endocytosis. Located in neuron projection terminus and synaptic vesicle. Part of AP-2 adaptor complex. Orthologous to human BTBD8 (BTB domain containing 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 143.1), Lung (RPKM 25.2) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Btbd8 in Genome Data Viewer
Location:
14p22
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (2410093..2483114, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (2265187..2338426, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (3282422..3351740, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene RNA polymerase II associated protein 2 Neighboring gene glomulin, FKBP associated protein Neighboring gene similar to human chromosome 1 open reading frame 146 Neighboring gene uncharacterized LOC108352691 Neighboring gene lysophosphatidylcholine acyltransferase 2b Neighboring gene epoxide hydrolase 4

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. APache Is an AP2-Interacting Protein Involved in Synaptic Vesicle Trafficking and Neuronal Development. Piccini A, et al. Cell Rep, 2017 Dec 19. PMID 29262337
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in synaptic vesicle budding from endosome ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of AP-2 adaptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon IEA
Inferred from Electronic Annotation
more info
  
is_active_in extrinsic component of synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in neuron projection terminus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
bTB/POZ domain-containing protein 8
Names
AP2-interacting clathrin-endocytosis protein
APache
BTB (POZ) domain containing 8
BTB/POZ domain-containing protein 8

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419526.1 → NP_001406455.1  bTB/POZ domain-containing protein 8

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/Swiss-Prot
    A0A452Q762, D4A0X3
    Related
    ENSRNOP00000038747.5, ENSRNOT00000037931.6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    2410093..2483114 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039092624.2 → XP_038948552.1  bTB/POZ domain-containing protein 8 isoform X2

    Conserved Domains (4) summary
    cd18285
    Location:43 → 146
    BTB1_POZ_BTBD8; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8)
    cd18286
    Location:189 → 308
    BTB2_POZ_BTBD8; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8)
    cd18490
    Location:316 → 377
    BACK_BTBD8; BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 8 (BTBD8)
    pfam15363
    Location:1724 → 1768
    DUF4596; Domain of unknown function (DUF4596)

  2. XM_039092625.2 → XP_038948553.1  bTB/POZ domain-containing protein 8 isoform X4

    Conserved Domains (4) summary
    cd18285
    Location:1 → 91
    BTB1_POZ_BTBD8; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8)
    cd18286
    Location:134 → 253
    BTB2_POZ_BTBD8; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8)
    cd18490
    Location:261 → 322
    BACK_BTBD8; BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 8 (BTBD8)
    pfam15363
    Location:1670 → 1714
    DUF4596; Domain of unknown function (DUF4596)

  3. XM_039092627.2 → XP_038948555.1  bTB/POZ domain-containing protein 8 isoform X5

    Conserved Domains (3) summary
    cd18285
    Location:43 → 146
    BTB1_POZ_BTBD8; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8)
    cd18286
    Location:189 → 308
    BTB2_POZ_BTBD8; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8)
    cd18490
    Location:316 → 377
    BACK_BTBD8; BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 8 (BTBD8)

  4. XM_006250597.5 → XP_006250659.2  bTB/POZ domain-containing protein 8 isoform X3

    Conserved Domains (5) summary
    smart00225
    Location:206 → 294
    BTB; Broad-Complex, Tramtrack and Bric a brac
    cd14821
    Location:405 → 452
    SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
    pfam00651
    Location:195 → 299
    BTB; BTB/POZ domain
    pfam15363
    Location:1707 → 1748
    DUF4596; Domain of unknown function (DUF4596)
    cl02518
    Location:51 → 125
    BTB; BTB/POZ domain

  5. XM_063272796.1 → XP_063128866.1  bTB/POZ domain-containing protein 8 isoform X6

  6. XM_039092623.2 → XP_038948551.1  bTB/POZ domain-containing protein 8 isoform X1

    Conserved Domains (4) summary
    cd18285
    Location:43 → 146
    BTB1_POZ_BTBD8; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8)
    cd18286
    Location:189 → 308
    BTB2_POZ_BTBD8; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8)
    cd18490
    Location:316 → 377
    BACK_BTBD8; BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 8 (BTBD8)
    pfam15363
    Location:1725 → 1769
    DUF4596; Domain of unknown function (DUF4596)

  7. XM_039092626.2 → XP_038948554.1  bTB/POZ domain-containing protein 8 isoform X4

    Conserved Domains (4) summary
    cd18285
    Location:1 → 91
    BTB1_POZ_BTBD8; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8)
    cd18286
    Location:134 → 253
    BTB2_POZ_BTBD8; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8)
    cd18490
    Location:261 → 322
    BACK_BTBD8; BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 8 (BTBD8)
    pfam15363
    Location:1670 → 1714
    DUF4596; Domain of unknown function (DUF4596)

  8. XM_039092629.2 → XP_038948557.1  bTB/POZ domain-containing protein 8 isoform X7

    Conserved Domains (2) summary
    pfam15363
    Location:1388 → 1432
    DUF4596; Domain of unknown function (DUF4596)
    cl28903
    Location:4 → 40
    BACK; BACK (BTB and C-terminal Kelch) domain

  9. XM_063272799.1 → XP_063128869.1  bTB/POZ domain-containing protein 8 isoform X10

  10. XM_063272798.1 → XP_063128868.1  bTB/POZ domain-containing protein 8 isoform X9

  11. XM_039092630.2 → XP_038948558.1  bTB/POZ domain-containing protein 8 isoform X8

    UniProtKB/TrEMBL
    A6KPJ4
    Conserved Domains (1) summary
    pfam15363
    Location:1189 → 1233
    DUF4596; Domain of unknown function (DUF4596)

  12. XM_063272797.1 → XP_063128867.1  bTB/POZ domain-containing protein 8 isoform X8

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D4A0X3.4 GenPept UniProtKB/Swiss-Prot:D4A0X3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools