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Rprd2 regulation of nuclear pre-mRNA domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100364568, updated on 27-Nov-2024

Summary

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Official Symbol
Rprd2provided by RGD
Official Full Name
regulation of nuclear pre-mRNA domain containing 2provided by RGD
Primary source
RGD:2320792
See related
EnsemblRapid:ENSRNOG00000054294 AllianceGenome:RGD:2320792
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable RNA polymerase II C-terminal domain binding activity. Predicted to be part of transcription preinitiation complex. Orthologous to human RPRD2 (regulation of nuclear pre-mRNA domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 75.9), Adrenal (RPKM 66.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rprd2 in Genome Data Viewer
Location:
2q34
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (186000375..186056943, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (183311132..183367959, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (197882666..197937844, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene extracellular matrix protein 1 Neighboring gene threonyl-tRNA synthetase 2, mitochondrial Neighboring gene transfer RNA proline (anticodon AGG) 87 Neighboring gene pre-mRNA processing factor 3 Neighboring gene mitochondrial ribosomal protein S21

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Control of the RNA polymerase II phosphorylation state in promoter regions by CTD interaction domain-containing proteins RPRD1A and RPRD1B. Ni Z, et al. Transcription, 2011 Sep-Oct. PMID 22231121, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA polymerase II C-terminal domain binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of transcription preinitiation complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
regulation of nuclear pre-mRNA domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427343.1 → NP_001414272.1  regulation of nuclear pre-mRNA domain-containing protein 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    Related
    ENSRNOP00000092500.2, ENSRNOT00000100824.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    186000375..186056943 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281096.1 → XP_063137166.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform X2

  2. XM_063281095.1 → XP_063137165.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AHR3
    Related
    ENSRNOP00000068661.3, ENSRNOT00000085404.3

  3. XM_008761344.4 → XP_008759566.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A0G2JTD1, A0A8I5ZS80
    Related
    ENSRNOP00000111227.1, ENSRNOT00000141383.1
    Conserved Domains (2) summary
    smart00582
    Location:27 → 145
    RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
    pfam16566
    Location:193 → 311
    CREPT; Cell-cycle alteration and expression-elevated protein in tumour

  4. XM_063281097.1 → XP_063137167.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform X5

  5. XM_039103792.2 → XP_038959720.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform X4

    Conserved Domains (3) summary
    PRK03918
    Location:142 → 318
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam05109
    Location:319 → 645
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd17001
    Location:27 → 146
    CID_RPRD2; CID (CTD-Interacting Domain) of Regulation of nuclear pre-mRNA domain-containing protein 2
Nucleotide Protein Strain
Heading Accession and Version

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