Mptx2 mucosal pentraxin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mptx2provided by MGI
Official Full Name: mucosal pentraxin 2provided by MGI
Primary source: MGI:MGI:3779286
See related: Ensembl:ENSMUSG00000079180 AllianceGenome:MGI:3779286
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm11062
Summary: Predicted to enable complement component C1q complex binding activity. Predicted to be involved in innate immune response. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in large intestine adult (RPKM 115.1), small intestine adult (RPKM 20.9) and 1 other tissue See more
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Genomic context

Location:: 1 H3; 1 80.33 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (173102028..173105323, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (173274461..173277756, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of Mptx2 alters bacteria composition and intestinal homeostasis potentially by impairing autophagy.
Title: Loss of Mptx2 alters bacteria composition and intestinal homeostasis potentially by impairing autophagy.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables complement component C1q complex binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Mucosal pentraxin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001205011.2 → NP_001191940.1 Mucosal pentraxin precursor

See identical proteins and their annotated locations for NP_001191940.1

Status: VALIDATED

Source sequence(s)

AC087781

Consensus CDS

CCDS56658.1

UniProtKB/TrEMBL

D3YYJ7

Related

ENSMUSP00000106855.4, ENSMUST00000111224.5

Conserved Domains (1) summary

cd00152
Location:20 → 214

PTX; Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated ...