IFITM3 interferon induced transmembrane protein 3 [Sus scrofa (pig)] - Gene

Summary

Gene symbol: IFITM3
Gene description: interferon induced transmembrane protein 3
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: IFITM2
Expression: Ubiquitous expression in ovary (RPKM 848.1), lung (RPKM 725.3) and 8 other tissues See more
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Genomic context

Location:: chromosome: 2

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	2	NC_010444.4 (128658..129736, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	2	NC_010444.3 (162072261..162072507, complement)

Chromosome 2 - NC_010444.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IFITM1 and IFITM2 inhibit the replication of senecavirus A by positive feedback with RIG-I signaling pathway.
Title: IFITM1 and IFITM2 inhibit the replication of senecavirus A by positive feedback with RIG-I signaling pathway.
Host antiviral protein IFITM2 restricts pseudorabies virus replication.
Title: Host antiviral protein IFITM2 restricts pseudorabies virus replication.
Interferon-Induced Transmembrane Protein 3 Is a Virus-Associated Protein Which Suppresses Porcine Reproductive and Respiratory Syndrome Virus Replication by Blocking Viral Membrane Fusion.
Title: Interferon-Induced Transmembrane Protein 3 Is a Virus-Associated Protein Which Suppresses Porcine Reproductive and Respiratory Syndrome Virus Replication by Blocking Viral Membrane Fusion.
S-palmitoylation of swine interferon-inducible transmembrane protein is essential for its anti-JEV activity.
Title: S-palmitoylation of swine interferon-inducible transmembrane protein is essential for its anti-JEV activity.
sIFITM3-TG pigs showed slightly higher susceptibility to FMDV infection than wild-type pigs
Title: Induction of systemic IFITM3 expression does not effectively control foot-and-mouth disease viral infection in transgenic pigs.
sIFITM3 inhibits foot-and-mouth disease virus infection.
Title: Swine interferon-induced transmembrane protein, sIFITM3, inhibits foot-and-mouth disease virus infection in vitro and in vivo.

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General gene information

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Gene Ontology Provided by RefSeq

Process	Evidence Code	Pubs
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of viral entry into host cell	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of viral genome replication	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to interferon-alpha	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to interferon-beta	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to type II interferon	IEA Inferred from Electronic Annotation more info	PubMed
involved_in type I interferon-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: interferon-induced transmembrane protein 3

Names: interferon induced transmembrane protein 2 (1-8D); interferon-induced transmembrane protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.