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GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough [ Homo sapiens (human) ]

Gene ID: 100527949, updated on 2-Nov-2024

Summary

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Official Symbol
GIMAP1-GIMAP5provided by HGNC
Official Full Name
GIMAP1-GIMAP5 readthroughprovided by HGNC
Primary source
HGNC:HGNC:51257
See related
Ensembl:ENSG00000281887 AllianceGenome:HGNC:51257
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This locus represents naturally occurring readthrough transcription between the neighboring GIMAP1 (GTPase, IMAP family member 1) and GIMAP5 (GTPase, IMAP family member 5) genes on chromosome 7. Alternative splicing results in multiple readthrough transcript variants, one of which encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Jan 2015]
Expression
Broad expression in lymph node (RPKM 55.4), spleen (RPKM 41.4) and 22 other tissues See more
Orthologs
all
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Genomic context

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See GIMAP1-GIMAP5 in Genome Data Viewer
Location:
7q36.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (150716613..150743646)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (151889523..151916554)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (150413701..150440734)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901774 Neighboring gene eukaryotic translation initiation factor 2A pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26841 Neighboring gene GTPase, IMAP family member 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150403727-150404226 Neighboring gene GTPase, IMAP family member 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26842 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:150432641-150433627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26843 Neighboring gene GTPase, IMAP family member 5 Neighboring gene GTPase, IMAP family member 3 pseudogene Neighboring gene Bet1 golgi vesicular membrane trafficking protein pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Human ortholog to mouse gene imap38 encoding an ER-localizable G-protein belongs to a gene family clustered on chromosome 7q32-36. Stamm O, et al. Gene, 2002 Jan 9. PMID 11814688
  2. Comparative analysis of the human gimap gene cluster encoding a novel GTPase family. Krücken J, et al. Gene, 2004 Oct 27. PMID 15474311
  3. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. Prakash T, et al. PLoS One, 2010 Oct 12. PMID 20967262, Free PMC Article
  4. Toward a complete human genome sequence. Sanger Center, et al. Genome Res, 1998 Nov. PMID 9847074

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

Homology

General protein information

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Preferred Names
GIMAP1-GIMAP5 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199577.2 → NP_001186506.1  GIMAP1-GIMAP5 protein isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC006479, FY213136
    UniProtKB/TrEMBL
    A0A087WTJ2
    Related
    ENSP00000477920.1, ENST00000611999.4
    Conserved Domains (2) summary
    cd01852
    Location:232 → 432
    AIG1; AvrRpt2-Induced Gene 1 (AIG1)
    pfam04548
    Location:28 → 135
    AIG1; AIG1 family

  2. NM_001303630.2 → NP_001290559.1  GIMAP1-GIMAP5 protein isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon, and it thus differs in its 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AC006479, FY210894
    UniProtKB/TrEMBL
    B4DNE2
    Conserved Domains (1) summary
    cd01852
    Location:104 → 304
    AIG1; AvrRpt2-Induced Gene 1 (AIG1)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    150716613..150743646
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    151889523..151916554
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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