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H2-T27 histocompatibility 2, T region locus 27 [ Mus musculus (house mouse) ]

Gene ID: 100529082, updated on 27-Nov-2024

Summary

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Official Symbol
H2-T27provided by MGI
Official Full Name
histocompatibility 2, T region locus 27provided by MGI
Primary source
MGI:MGI:3779381
See related
Ensembl:ENSMUSG00000079492
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H-2T15; H2-T15; Gm11127; H2-gs14-2
Expression
Broad expression in duodenum adult (RPKM 140.0), small intestine adult (RPKM 139.5) and 15 other tissues See more
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Genomic context

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See H2-T27 in Genome Data Viewer
Location:
17 18.88 cM; 17 B1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (36366708..36369346, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (36055816..36058371, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A930015D03 gene Neighboring gene STARR-positive B cell enhancer ABC_E168 Neighboring gene histocompatibility 2, T region locus 22 Neighboring gene predicted gene 6034 Neighboring gene predicted gene, 54001 Neighboring gene histocompatibility 2, D region locus 1 pseudogene Neighboring gene predicted gene 8810 Neighboring gene histocompatibility 2, blastocyst

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Extension of the H-2 TLb molecular map. Isolation and characterization of T13, T14, and T15 from the C57BL/6 mouse. Brown GD, et al. Immunogenetics, 1988. PMID 2831142
  2. Major histocompatibility complex (Mhc) class Ib gene duplications, organization and expression patterns in mouse strain C57BL/6. Ohtsuka M, et al. BMC Genomics, 2008 Apr 17. PMID 18416856, Free PMC Article
  3. A physical map of the Q region of B1O.P. Litaker W, et al. Mamm Genome, 1996 Mar. PMID 8833240
  4. Clusters of genes encoding mouse transplantation antigens. Steinmetz M, et al. Cell, 1982 Mar. PMID 6280871
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables peptide antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of T cell mediated cytotoxicity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
predicted gene 11127
Names
H2-GS14-2 antigen
MHC class I like protein GS14-2
histocompatibility 2, T region locus 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199967.2 → NP_001186896.1  predicted gene 11127 precursor

    See identical proteins and their annotated locations for NP_001186896.1

    Status: VALIDATED

    Source sequence(s)
    CT030728
    Consensus CDS
    CCDS57078.1
    UniProtKB/TrEMBL
    A7VMS2
    Related
    ENSMUSP00000109371.3, ENSMUST00000113742.3
    Conserved Domains (2) summary
    pfam00129
    Location:27 → 198
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    cd21016
    Location:204 → 298
    IgC1_MHC_Ib_T10_T22_like; Class Ib major histocompatibility complex (MHC) immunoglobulin domain of T10, T22, and similar proteins; member of the C1-set of Ig superfamily (IgSF) domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    36366708..36369346 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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