dio3a iodothyronine deiodinase 3a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dio3aprovided by ZNC
Official Full Name: iodothyronine deiodinase 3aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-120406-7
See related: AllianceGenome:ZFIN:ZDB-GENE-120406-7
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. Two paralogs of this gene have been identified in zebrafish on chromosomes 17 and 20. Both encode enzymatically active proteins; however, their gene structure and tissue expression patterns are markedly different. This gene is intronless, like orthologs in all other vertebrate species studied to date, but unlike the paralog on chromosome 20, which is 2-exon. Knockdown of this gene indicates that it is essential for normal zebrafish embryonic and early larval development. This protein is a selenoprotein, containing the rare selenocysteine (Sec) amino acid at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2017]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (842102..843241, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (1387812..1388951, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A critical role for reduced intracellular TH concentrations in neutrophil function during infection, for which the TH inactivating enzyme D3 appears essential.
Title: The Thyroid Hormone Inactivating Type 3 Deiodinase Is Essential for Optimal Neutrophil Function: Observations From Three Species.
Dio3 expression controls zebrafish embryo size.
Title: Intrinsic expression of a multiexon type 3 deiodinase gene controls zebrafish embryo size.

Submit: New GeneRIF Correction

General gene information

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Markers

fl13d01.x1 (e-PCR)
- UniSTS:201992

G47286 (e-PCR)
- UniSTS:108069

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables thyroxine 5'-deiodinase activity	IDA Inferred from Direct Assay more info	PubMed
enables thyroxine 5'-deiodinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chordate embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hormone biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: iodothyronine deiodinase 3a

Names: deiodinase, iodothyronine, type IIIa

NP_001242932.1

EC 1.21.99.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001256003.1 → NP_001242932.1 iodothyronine deiodinase 3a

Status: REVIEWED

Source sequence(s)

BE557694, EH432430, EH458785

UniProtKB/TrEMBL

A0A8M1P485

Conserved Domains (1) summary

cl00388
Location:11 → 253

Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold