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Lrrc8c leucine rich repeat containing 8 family, member C [ Mus musculus (house mouse) ]

Gene ID: 100604, updated on 27-Nov-2024

Summary

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Official Symbol
Lrrc8cprovided by MGI
Official Full Name
leucine rich repeat containing 8 family, member Cprovided by MGI
Primary source
MGI:MGI:2140839
See related
Ensembl:ENSMUSG00000054720 AllianceGenome:MGI:2140839
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AD158; fad158; E430036I04Rik
Summary
Contributes to volume-sensitive anion channel activity. Involved in monoatomic anion transmembrane transport and protein hexamerization. Acts upstream of or within fat cell differentiation. Located in endoplasmic reticulum. Part of monoatomic ion channel complex. Is expressed in retina. Orthologous to human LRRC8C (leucine rich repeat containing 8 VRAC subunit C). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in lung adult (RPKM 8.8), thymus adult (RPKM 7.7) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Lrrc8c in Genome Data Viewer
Location:
5 E5; 5 50.68 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (105666850..105760884)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (105519345..105613018)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6355 Neighboring gene predicted gene, 42141 Neighboring gene predicted gene, 42144 Neighboring gene STARR-seq mESC enhancer starr_13855 Neighboring gene STARR-positive B cell enhancer mm9_chr5:105986877-105987177 Neighboring gene STARR-seq mESC enhancer starr_13856 Neighboring gene STARR-seq mESC enhancer starr_13857 Neighboring gene STARR-positive B cell enhancer ABC_E11298 Neighboring gene STARR-positive B cell enhancer ABC_E3592 Neighboring gene STARR-positive B cell enhancer ABC_E4771 Neighboring gene STARR-positive B cell enhancer ABC_E4772 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:106077733-106078005 Neighboring gene STARR-positive B cell enhancer ABC_E11299 Neighboring gene predicted gene, 32230 Neighboring gene STARR-positive B cell enhancer ABC_E6356 Neighboring gene predicted gene, 32276

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Factor for adipocyte differentiation 158 gene disruption prevents the body weight gain and insulin resistance induced by a high-fat diet. Hayashi T, et al. Biol Pharm Bull, 2011. PMID 21804215
  2. Structure of a volume-regulated heteromeric LRRC8A/C channel. Rutz S, et al. Nat Struct Mol Biol, 2023 Jan. PMID 36522427, Free PMC Article
  3. Renal Deletion of LRRC8/VRAC Channels Induces Proximal Tubulopathy. López-Cayuqueo KI, et al. J Am Soc Nephrol, 2022 Aug. PMID 35777784, Free PMC Article
  4. Structure of a volume-regulated anion channel of the LRRC8 family. Deneka D, et al. Nature, 2018 Jun. PMID 29769723
  5. The novel gene fad158, having a transmembrane domain and leucine-rich repeat, stimulates adipocyte differentiation. Tominaga K, et al. J Biol Chem, 2004 Aug 13. PMID 15184384

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structure of a volume-regulated heteromeric LRRC8A/C channel.
    Title: Structure of a volume-regulated heteromeric LRRC8A/C channel.
  2. These results indicate that fad158 is a key factor in the development of obesity and insulin resistance caused by a high-fat diet.
    Title: Factor for adipocyte differentiation 158 gene disruption prevents the body weight gain and insulin resistance induced by a high-fat diet.
  3. fad158 has a role in regulating adipocyte differentiation
    Title: The novel gene fad158, having a transmembrane domain and leucine-rich repeat, stimulates adipocyte differentiation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to volume-sensitive anion channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
contributes_to volume-sensitive anion channel activity ISO
Inferred from Sequence Orthology
more info
  
enables volume-sensitive anion channel activity ISO
Inferred from Sequence Orthology
more info
  
enables volume-sensitive anion channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in aspartate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in aspartate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in aspartate transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to osmotic stress IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to osmotic stress ISO
Inferred from Sequence Orthology
more info
  
involved_in cyclic-GMP-AMP transmembrane import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cyclic-GMP-AMP transmembrane import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in cyclic-GMP-AMP transmembrane import across plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within fat cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic anion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic anion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic anion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in monoatomic anion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein hexamerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in taurine transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in taurine transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
part_of monoatomic ion channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of monoatomic ion channel complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of monoatomic ion channel complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
volume-regulated anion channel subunit LRRC8C
Names
factor for adipocyte differentiation 158
leucine-rich repeat-containing protein 8C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133897.2 → NP_598658.1  volume-regulated anion channel subunit LRRC8C

    See identical proteins and their annotated locations for NP_598658.1

    Status: PROVISIONAL

    Source sequence(s)
    AC122566, AC138265
    Consensus CDS
    CCDS19493.1
    UniProtKB/Swiss-Prot
    Q3TEP9, Q8C296, Q8R0N7, Q8R3G5, Q8R502
    Related
    ENSMUSP00000066015.7, ENSMUST00000067924.13
    Conserved Domains (3) summary
    COG4886
    Location:528 → 775
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:591 → 613
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1 → 338
    Pannexin_like; Pannexin-like TM region of LRRC8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    105666850..105760884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534685.4 → XP_006534748.1  volume-regulated anion channel subunit LRRC8C isoform X1

    See identical proteins and their annotated locations for XP_006534748.1

    UniProtKB/Swiss-Prot
    Q3TEP9, Q8C296, Q8R0N7, Q8R3G5, Q8R502
    Conserved Domains (3) summary
    COG4886
    Location:528 → 775
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:591 → 613
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1 → 338
    Pannexin_like; Pannexin-like TM region of LRRC8

  2. XM_017320573.2 → XP_017176062.1  volume-regulated anion channel subunit LRRC8C isoform X1

    UniProtKB/Swiss-Prot
    Q3TEP9, Q8C296, Q8R0N7, Q8R3G5, Q8R502
    Conserved Domains (3) summary
    COG4886
    Location:528 → 775
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:591 → 613
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1 → 338
    Pannexin_like; Pannexin-like TM region of LRRC8

  3. XM_006534686.5 → XP_006534749.1  volume-regulated anion channel subunit LRRC8C isoform X2

    Conserved Domains (3) summary
    COG4886
    Location:481 → 728
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:544 → 566
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1 → 291
    Pannexin_like; Pannexin-like TM region of LRRC8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R502.1 GenPept UniProtKB/Swiss-Prot:Q8R502

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