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STAT6 signal transducer and activator of transcription 6 [ Loxodonta africana (African savanna elephant) ]

Gene ID: 100675819, updated on 11-Apr-2024

Summary

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Gene symbol
STAT6
Gene description
signal transducer and activator of transcription 6
See related
EnsemblRapid:ENSLAFG00000005970
Gene type
protein coding
RefSeq status
MODEL
Organism
Loxodonta africana
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta
Orthologs
human mouse all
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Genomic context

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See STAT6 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_04 current mLoxAfr1.hap2 (GCF_030014295.1) 4 NC_087345.1 (80237681..80253026)
102 previous assembly Loxafr3.0 (GCF_000001905.1) Unplaced Scaffold NW_003573422.1 (46404741..46420487, complement)

Chromosome 4 - NC_087345.1Genomic Context describing neighboring genes Neighboring gene LDL receptor related protein 1 Neighboring gene uncharacterized LOC111752779 Neighboring gene ras-related protein Rab-5B-like Neighboring gene uncharacterized LOC135231198 Neighboring gene NGFI-A binding protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in defense response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in growth hormone receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to peptide hormone IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
signal transducer and activator of transcription 6

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_030014295.1-RS_2024_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mLoxAfr1.hap2

Genomic

  1. NC_087345.1 Reference mLoxAfr1.hap2

    Range
    80237681..80253026
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023557874.2 → XP_023413642.1  signal transducer and activator of transcription 6 isoform X3

    Conserved Domains (5) summary
    smart00964
    Location:2 → 115
    STAT_int; STAT protein, protein interaction domain
    pfam14596
    Location:608 → 801
    STAT6_C; STAT6 C-terminal
    pfam01017
    Location:124 → 273
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:275 → 528
    STAT_bind; STAT protein, DNA binding domain
    cl15255
    Location:519 → 583
    SH2; Src homology 2 (SH2) domain

  2. XM_023557862.2 → XP_023413630.1  signal transducer and activator of transcription 6 isoform X1

    Conserved Domains (5) summary
    cd10377
    Location:519 → 648
    SH2_STAT6; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 6 proteins
    smart00964
    Location:2 → 115
    STAT_int; STAT protein, protein interaction domain
    pfam14596
    Location:657 → 850
    STAT6_C; STAT6 C-terminal
    pfam01017
    Location:124 → 273
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:275 → 528
    STAT_bind; STAT protein, DNA binding domain

  3. XM_023557867.2 → XP_023413635.1  signal transducer and activator of transcription 6 isoform X2

    UniProtKB/TrEMBL
    G3SX92
    Related
    ENSLAFP00000040953.1, ENSLAFT00000055693.1
    Conserved Domains (5) summary
    cd10377
    Location:519 → 648
    SH2_STAT6; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 6 proteins
    smart00964
    Location:2 → 115
    STAT_int; STAT protein, protein interaction domain
    pfam14596
    Location:657 → 849
    STAT6_C; STAT6 C-terminal
    pfam01017
    Location:124 → 273
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:275 → 528
    STAT_bind; STAT protein, DNA binding domain
Nucleotide Protein
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