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IL18BP interleukin 18 binding protein [ Homo sapiens (human) ]

Gene ID: 10068, updated on 27-Nov-2024

Summary

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Official Symbol
IL18BPprovided by HGNC
Official Full Name
interleukin 18 binding proteinprovided by HGNC
Primary source
HGNC:HGNC:5987
See related
Ensembl:ENSG00000137496 MIM:604113; AllianceGenome:HGNC:5987
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FVH; IL18BPa
Summary
The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
Expression
Broad expression in spleen (RPKM 11.4), appendix (RPKM 6.6) and 24 other tissues See more
Orthologs
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Genomic context

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See IL18BP in Genome Data Viewer
Location:
11q13.4
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (71998909..72008200)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (71925824..71929835)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (71709955..71713965)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene XNDC1N-ZNF705EP-ALG1L9P readthrough Neighboring gene XRCC1 N-terminal domain containing 1, N-terminal like Neighboring gene olfactory receptor family 7 subfamily E member 126 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5171 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:71660091-71661028 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:71661029-71661964 Neighboring gene ring finger protein 121 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5172 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5173 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5175 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5174 Neighboring gene uncharacterized LOC100128494 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:71725991-71726738 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:71728895-71730094 Neighboring gene Sharpr-MPRA regulatory region 3523 Neighboring gene nuclear mitotic apparatus protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5176 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:71751839-71752624 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:71752625-71753408 Neighboring gene uncharacterized LOC124902815

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Interleukin-18 binding protein regulates the apoptosis and necroptosis of fibroblast-like synoviocytes and chondrocytes in rheumatoid arthritis. Min HK, et al. Clin Exp Rheumatol, 2023 Nov. PMID 37083154
  2. Serum levels of interleukin-18-binding protein isoform a: Clinical association with inflammation and pulmonary hypertension in systemic sclerosis. Nakamura K, et al. J Dermatol, 2016 Aug. PMID 26777734
  3. Failure of interferon gamma to induce the anti-inflammatory interleukin 18 binding protein in familial hemophagocytosis. Nold-Petry CA, et al. PLoS One, 2010 Jan 13. PMID 20072626, Free PMC Article
  4. IL-18BP is decreased in osteoporotic women: Prevents Inflammasome mediated IL-18 activation and reduces Th17 differentiation. Mansoori MN, et al. Sci Rep, 2016 Sep 21. PMID 27649785, Free PMC Article
  5. A potentially protective role of IL-18 Binding Protein in HIV-infected Long-Term Non-Progressors. Iannello A, et al. Cytokine, 2017 Feb. PMID 27863336

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interleukin-18 binding protein regulates the apoptosis and necroptosis of fibroblast-like synoviocytes and chondrocytes in rheumatoid arthritis.
    Title: Interleukin-18 binding protein regulates the apoptosis and necroptosis of fibroblast-like synoviocytes and chondrocytes in rheumatoid arthritis.
  2. Level of interleukin-18 binding protein is significantly different in patients with anaphylaxis than urticaria.
    Title: Level of interleukin-18 binding protein is significantly different in patients with anaphylaxis than urticaria.
  3. Interleukin-18 and IL-18BP in inflammatory dermatological diseases.
    Title: Interleukin-18 and IL-18BP in inflammatory dermatological diseases.
  4. Caspase-1 and interleukin-18 in children with post infectious bronchiolitis obliterans: a case-control study.
    Title: Caspase-1 and interleukin-18 in children with post infectious bronchiolitis obliterans: a case-control study.
  5. Structural basis of human IL-18 sequestration by the decoy receptor IL-18 binding protein in inflammation and tumor immunity.
    Title: Structural basis of human IL-18 sequestration by the decoy receptor IL-18 binding protein in inflammation and tumor immunity.
  6. Balance between Interleukin-18 and Interleukin-18 binding protein in auto-inflammatory diseases.
    Title: Balance between Interleukin-18 and Interleukin-18 binding protein in auto-inflammatory diseases.
  7. Interleukin-18 binding protein in infants and children hospitalized with pneumonia in low-resource settings.
    Title: Interleukin-18 binding protein in infants and children hospitalized with pneumonia in low-resource settings.
  8. IL-18 binding protein suppresses IL-17-induced osteoclastogenesis and rectifies type 17 helper T cell / regulatory T cell imbalance in rheumatoid arthritis.
    Title: IL-18 binding protein suppresses IL-17-induced osteoclastogenesis and rectifies type 17 helper T cell / regulatory T cell imbalance in rheumatoid arthritis.
  9. IL-18 and IL-18 binding protein are related to disease severity and parasitemia during falciparum malaria.
    Title: IL-18 and IL-18 binding protein are related to disease severity and parasitemia during falciparum malaria.
  10. IL-18 and IL-18 binding protein concentration in ovarian follicular fluid of women with unexplained infertility to PCOS during in vitro fertilization.
    Title: IL-18 and IL-18 binding protein concentration in ovarian follicular fluid of women with unexplained infertility to PCOS during in vitro fertilization.
Submit: New GeneRIF Correction See all GeneRIFs (50)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Hepatitis, fulminant viral, susceptibility to
MedGen: C5231406 OMIM: 618549 GeneReviews: Not available
Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables interleukin-18 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-18 binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables receptor antagonist activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in T-helper 1 type immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in T-helper 1 type immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
  
involved_in response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
interleukin-18-binding protein
Names
MC51L-53L-54L homolog gene product
tadekinig-alfa

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029021.2 RefSeqGene

    Range
    5002..8897
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001039659.2 → NP_001034748.1  interleukin-18-binding protein isoform a precursor

    See identical proteins and their annotated locations for NP_001034748.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (E) differs in the 5' UTR compared to variant A. Variants A, E, F and G encode the same isoform (a, also known as IL-18BPa).
    Source sequence(s)
    AF110799, AP002490, AW295729, BX357194
    Consensus CDS
    CCDS8206.2
    UniProtKB/Swiss-Prot
    B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7
    UniProtKB/TrEMBL
    Q9UNH2
    Related
    ENSP00000377308.4, ENST00000393705.8
    Conserved Domains (1) summary
    cl23951
    Location:79 → 169
    Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein

  2. NM_001039660.2 → NP_001034749.1  interleukin-18-binding protein isoform a precursor

    See identical proteins and their annotated locations for NP_001034749.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (F) differs in the 5' UTR compared to variant A. Variants A, E, F and G encode the same isoform (a, also known as IL-18BPa).
    Source sequence(s)
    AF110799, AP002490, AW295729, BX357194, CB154498
    Consensus CDS
    CCDS8206.2
    UniProtKB/Swiss-Prot
    B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7
    UniProtKB/TrEMBL
    Q9UNH2
    Related
    ENSP00000377306.4, ENST00000393703.9
    Conserved Domains (1) summary
    cl23951
    Location:79 → 169
    Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein

  3. NM_001145055.1 → NP_001138527.1  interleukin-18-binding protein isoform b precursor

    See identical proteins and their annotated locations for NP_001138527.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (H) lacks two internal exons in the 3' coding region compared to variant A, which results in a frame-shift and a shorter isoform (b, also known as IL-18BPb) with a distinct C-terminus compared to isoform a. This isoform lacks the ability to bind IL-18 (PMID:10655506).
    Source sequence(s)
    AF110800, AW295729
    Consensus CDS
    CCDS44666.1
    Related
    ENSP00000377310.4, ENST00000393707.4

  4. NM_001145057.1 → NP_001138529.1  interleukin-18-binding protein isoform a precursor

    See identical proteins and their annotated locations for NP_001138529.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (G) differs in the 5' UTR compared to variant A. Variants A, E, F and G encode the same isoform (a, also known as IL-18BPa).
    Source sequence(s)
    AF122906, AW295729, BM819966
    Consensus CDS
    CCDS8206.2
    UniProtKB/Swiss-Prot
    B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7
    UniProtKB/TrEMBL
    Q9UNH2
    Conserved Domains (1) summary
    cl23951
    Location:79 → 169
    Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein

  5. NM_005699.3 → NP_005690.2  interleukin-18-binding protein isoform c precursor

    See identical proteins and their annotated locations for NP_005690.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (C) is alternatively spliced in the 3' coding region compared to variant A. This results in a frame-shift, and a longer isoform (c, also known as IL-18BPc) with a distinct C-terminus compared to isoform a. This isoform retains the ability to bind IL-18 (PMID:10655506).
    Source sequence(s)
    AF110799, AF110801, AL698586
    Consensus CDS
    CCDS8207.2
    UniProtKB/TrEMBL
    A0A024R5M6, G3V1C5
    Related
    ENSP00000434717.1, ENST00000497194.6
    Conserved Domains (1) summary
    cl23951
    Location:79 → 169
    Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein

  6. NM_173042.2 → NP_766630.2  interleukin-18-binding protein isoform a precursor

    See identical proteins and their annotated locations for NP_766630.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (A) encodes the predominant isoform (a, also known as IL-18BPa), which shows the highest affinity for binding IL-18 (PMID:10655506). Variants A, E, F and G encode the same isoform.
    Source sequence(s)
    AF110799, AF110801, AW295729
    Consensus CDS
    CCDS8206.2
    UniProtKB/Swiss-Prot
    B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7
    UniProtKB/TrEMBL
    Q9UNH2
    Related
    ENSP00000384212.1, ENST00000404792.5
    Conserved Domains (1) summary
    cl23951
    Location:79 → 169
    Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein

  7. NM_173044.3 → NP_766632.2  interleukin-18-binding protein isoform d precursor

    See identical proteins and their annotated locations for NP_766632.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (D) differs in the 5' UTR and uses an alternate donor splice site at the penultimate coding exon compared to variant A. This results in a frame-shift and a shorter isoform (d, also known as IL-18BPd) with a distinct C-terminus compared to isoform a. This isoform lacks the ability to bind IL-18 (PMID:10655506).
    Source sequence(s)
    AF215907, AP002490, CB154498
    Consensus CDS
    CCDS8205.1
    Related
    ENSP00000480621.1, ENST00000620017.4
    Conserved Domains (1) summary
    cl23951
    Location:79 → 122
    Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    71998909..72008200
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426203.1 → XP_047282159.1  interleukin-18-binding protein isoform X1

    UniProtKB/Swiss-Prot
    B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7
    Related
    ENSP00000513973.1, ENST00000698837.1

  2. XM_047426206.1 → XP_047282162.1  interleukin-18-binding protein isoform X1

    UniProtKB/Swiss-Prot
    B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7
    Related
    ENSP00000513975.1, ENST00000698839.1

  3. XM_047426207.1 → XP_047282163.1  interleukin-18-binding protein isoform X1

    UniProtKB/Swiss-Prot
    B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7

  4. XM_017017059.2 → XP_016872548.1  interleukin-18-binding protein isoform X1

    UniProtKB/Swiss-Prot
    B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7
    UniProtKB/TrEMBL
    Q9UNH2
    Conserved Domains (1) summary
    cl23951
    Location:79 → 169
    Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein

  5. XM_017017061.3 → XP_016872550.1  interleukin-18-binding protein isoform X1

    UniProtKB/Swiss-Prot
    B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7
    UniProtKB/TrEMBL
    Q9UNH2
    Conserved Domains (1) summary
    cl23951
    Location:79 → 169
    Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein

  6. XM_047426205.1 → XP_047282161.1  interleukin-18-binding protein isoform X1

    UniProtKB/Swiss-Prot
    B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7
    Related
    ENSP00000338723.5, ENST00000337131.9

  7. XM_047426204.1 → XP_047282160.1  interleukin-18-binding protein isoform X1

    UniProtKB/Swiss-Prot
    B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7

  8. XM_024448304.2 → XP_024304072.1  interleukin-18-binding protein isoform X1

    UniProtKB/Swiss-Prot
    B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7
    UniProtKB/TrEMBL
    Q9UNH2
    Conserved Domains (1) summary
    cl23951
    Location:79 → 169
    Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein

  9. XM_047426208.1 → XP_047282164.1  interleukin-18-binding protein isoform X1

    UniProtKB/Swiss-Prot
    B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7

  10. XM_017017063.2 → XP_016872552.1  interleukin-18-binding protein isoform X1

    UniProtKB/Swiss-Prot
    B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7
    UniProtKB/TrEMBL
    Q9UNH2
    Conserved Domains (1) summary
    cl23951
    Location:79 → 169
    Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein

  11. XM_024448303.2 → XP_024304071.1  interleukin-18-binding protein isoform X1

    UniProtKB/Swiss-Prot
    B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7
    UniProtKB/TrEMBL
    Q9UNH2
    Conserved Domains (1) summary
    cl23951
    Location:79 → 169
    Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    71925824..71929835
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367385.1 → XP_054223360.1  interleukin-18-binding protein isoform X1

    UniProtKB/Swiss-Prot
    B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7

  2. XM_054367386.1 → XP_054223361.1  interleukin-18-binding protein isoform X1

    UniProtKB/Swiss-Prot
    B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7

  3. XM_054367387.1 → XP_054223362.1  interleukin-18-binding protein isoform X1

    UniProtKB/Swiss-Prot
    B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7

  4. XM_054367390.1 → XP_054223365.1  interleukin-18-binding protein isoform X1

    UniProtKB/Swiss-Prot
    B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7

  5. XM_054367392.1 → XP_054223367.1  interleukin-18-binding protein isoform X1

    UniProtKB/Swiss-Prot
    B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7

  6. XM_054367388.1 → XP_054223363.1  interleukin-18-binding protein isoform X1

    UniProtKB/Swiss-Prot
    B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7

  7. XM_054367394.1 → XP_054223369.1  interleukin-18-binding protein isoform X1

    UniProtKB/Swiss-Prot
    B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7

  8. XM_054367391.1 → XP_054223366.1  interleukin-18-binding protein isoform X1

    UniProtKB/Swiss-Prot
    B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7

  9. XM_054367393.1 → XP_054223368.1  interleukin-18-binding protein isoform X1

    UniProtKB/Swiss-Prot
    B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7

  10. XM_054367389.1 → XP_054223364.1  interleukin-18-binding protein isoform X1

    UniProtKB/Swiss-Prot
    B3KUZ0, B7WPK4, O95993, O95998, O96027, Q9NZA9, Q9UBR7

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_173043.1: Suppressed sequence

    Description
    NM_173043.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95998.2 GenPept UniProtKB/Swiss-Prot:O95998

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