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RASGRF2 Ras protein specific guanine nucleotide releasing factor 2 [ Gallus gallus (chicken) ]

Gene ID: 100859132, updated on 3-Dec-2024

Summary

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Symbol
RASGRF2provided by CGNC
Full Name
Ras protein specific guanine nucleotide releasing factor 2provided by CGNC
Primary source
CGNC:66088
See related
Ensembl:ENSGALG00010007166
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See RASGRF2 in Genome Data Viewer
Location:
chromosome: Z
Exon count:
29
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) Z NC_052572.1 (64500889..64628065, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) Z NC_059536.1 (64500889..64628065, complement)

Chromosome Z - NC_052572.1Genomic Context describing neighboring genes Neighboring gene zinc finger CCHC-type containing 9 Neighboring gene creatine kinase, mitochondrial 2 Neighboring gene uncharacterized LOC107052408 Neighboring gene mutS homolog 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ras-specific guanine nucleotide-releasing factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052572.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    64500889..64628065 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003643077.6 → XP_003643125.1  ras-specific guanine nucleotide-releasing factor 2 isoform X4

    UniProtKB/TrEMBL
    A0A8V0XMW3
    Conserved Domains (8) summary
    smart00147
    Location:999 → 1235
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:901 → 973
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    smart00233
    Location:479 → 587
    PH; Pleckstrin homology domain
    cd13261
    Location:19 → 157
    PH_RasGRF1_2; Ras-specific guanine nucleotide-releasing factors 1 and 2 Pleckstrin homology (PH) domain
    pfam00169
    Location:24 → 132
    PH; PH domain
    pfam00618
    Location:637 → 686
    RasGEF_N; RasGEF N-terminal motif
    pfam00621
    Location:246 → 427
    RhoGEF; RhoGEF domain
    pfam08418
    Location:725 → 814
    Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal

  2. XM_004949460.5 → XP_004949517.1  ras-specific guanine nucleotide-releasing factor 2 isoform X3

    UniProtKB/TrEMBL
    A0A8V0XMW3, A0A8V0XU59
    Related
    ENSGALP00010009529.1, ENSGALT00010017091.1
    Conserved Domains (8) summary
    smart00147
    Location:1000 → 1236
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:902 → 974
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    smart00233
    Location:479 → 587
    PH; Pleckstrin homology domain
    cd13261
    Location:19 → 157
    PH_RasGRF1_2; Ras-specific guanine nucleotide-releasing factors 1 and 2 Pleckstrin homology (PH) domain
    pfam00169
    Location:24 → 132
    PH; PH domain
    pfam00618
    Location:637 → 686
    RasGEF_N; RasGEF N-terminal motif
    pfam00621
    Location:246 → 427
    RhoGEF; RhoGEF domain
    pfam08418
    Location:725 → 814
    Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal

  3. XM_015280710.4 → XP_015136196.1  ras-specific guanine nucleotide-releasing factor 2 isoform X2

    UniProtKB/TrEMBL
    A0A8V0XMW3
    Conserved Domains (8) summary
    smart00147
    Location:1033 → 1269
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:935 → 1007
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    smart00233
    Location:513 → 621
    PH; Pleckstrin homology domain
    cd13261
    Location:19 → 157
    PH_RasGRF1_2; Ras-specific guanine nucleotide-releasing factors 1 and 2 Pleckstrin homology (PH) domain
    pfam00169
    Location:24 → 132
    PH; PH domain
    pfam00618
    Location:671 → 720
    RasGEF_N; RasGEF N-terminal motif
    pfam00621
    Location:246 → 461
    RhoGEF; RhoGEF domain
    pfam08418
    Location:759 → 848
    Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal

  4. XM_015280709.4 → XP_015136195.1  ras-specific guanine nucleotide-releasing factor 2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0XMW3
    Conserved Domains (8) summary
    smart00147
    Location:1034 → 1270
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:936 → 1008
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    smart00233
    Location:513 → 621
    PH; Pleckstrin homology domain
    cd13261
    Location:19 → 157
    PH_RasGRF1_2; Ras-specific guanine nucleotide-releasing factors 1 and 2 Pleckstrin homology (PH) domain
    pfam00169
    Location:24 → 132
    PH; PH domain
    pfam00618
    Location:671 → 720
    RasGEF_N; RasGEF N-terminal motif
    pfam00621
    Location:246 → 461
    RhoGEF; RhoGEF domain
    pfam08418
    Location:759 → 848
    Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal

  5. XM_015280711.4 → XP_015136197.1  ras-specific guanine nucleotide-releasing factor 2 isoform X5

    Conserved Domains (7) summary
    smart00233
    Location:513 → 621
    PH; Pleckstrin homology domain
    cd13261
    Location:19 → 157
    PH_RasGRF1_2; Ras-specific guanine nucleotide-releasing factors 1 and 2 Pleckstrin homology (PH) domain
    pfam00169
    Location:24 → 132
    PH; PH domain
    pfam00618
    Location:671 → 720
    RasGEF_N; RasGEF N-terminal motif
    pfam00621
    Location:246 → 461
    RhoGEF; RhoGEF domain
    pfam08418
    Location:759 → 848
    Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
    cl02520
    Location:936 → 968
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

RNA

  1. XR_005843209.2 RNA Sequence

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_059536.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    64500889..64628065 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046937020.1 → XP_046792976.1  ras-specific guanine nucleotide-releasing factor 2 isoform X4

    UniProtKB/TrEMBL
    A0A8V0XMW3

  2. XM_046937019.1 → XP_046792975.1  ras-specific guanine nucleotide-releasing factor 2 isoform X3

    UniProtKB/TrEMBL
    A0A8V0XMW3, A0A8V0XU59

  3. XM_046937018.1 → XP_046792974.1  ras-specific guanine nucleotide-releasing factor 2 isoform X2

    UniProtKB/TrEMBL
    A0A8V0XMW3

  4. XM_046937017.1 → XP_046792973.1  ras-specific guanine nucleotide-releasing factor 2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0XMW3

  5. XM_046937021.1 → XP_046792977.1  ras-specific guanine nucleotide-releasing factor 2 isoform X5

RNA

  1. XR_006938061.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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