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NAMPT nicotinamide phosphoribosyltransferase [ Homo sapiens (human) ]

Gene ID: 10135, updated on 27-Nov-2024

Summary

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Official Symbol
NAMPTprovided by HGNC
Official Full Name
nicotinamide phosphoribosyltransferaseprovided by HGNC
Primary source
HGNC:HGNC:30092
See related
Ensembl:ENSG00000105835 MIM:608764; AllianceGenome:HGNC:30092
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VF; PBEF; PBEF1; VISFATIN; 1110035O14Rik
Summary
This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic acid phosphoribosyltransferase (NAPRTase) family and is thought to be involved in many important biological processes, including metabolism, stress response and aging. This gene has a pseudogene on chromosome 10. [provided by RefSeq, Feb 2011]
Expression
Broad expression in appendix (RPKM 222.0), bone marrow (RPKM 154.0) and 20 other tissues See more
Orthologs
mouse all
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Genomic context

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See NAMPT in Genome Data Viewer
Location:
7q22.3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (106248298..106285888, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (107563712..107602631, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (105888744..105925429, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901719 Neighboring gene RNA, U6 small nuclear 392, pseudogene Neighboring gene MPRA-validated peak6672 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr7:105900446-105900972 Neighboring gene NANOG hESC enhancer GRCh37_chr7:105900973-105901497 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18532 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18533 Neighboring gene NAMPT antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18534 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:105960332-105961531 Neighboring gene LARP1B pseudogene 2 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:105986583-105987782 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:106014918-106015131 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:106041193-106041886 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:106065201-106066400 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:106089346-106090545 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26485 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:106206739-106207704 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:106207705-106208670 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:106208671-106209636 Neighboring gene uncharacterized CTB-30L5.1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Inhibitor of Nicotinamide Phosphoribosyltransferase Sensitizes Glioblastoma Cells to Temozolomide via Activating ROS/JNK Signaling Pathway. Feng J, et al. Biomed Res Int, 2016. PMID 28097126, Free PMC Article
  2. Replicative Senescence in Human Fibroblasts Is Delayed by Hydrogen Sulfide in a NAMPT/SIRT1 Dependent Manner. Sanokawa-Akakura R, et al. PLoS One, 2016. PMID 27732642, Free PMC Article
  3. Circulating visfatin level is associated with hepatocellular carcinoma in chronic hepatitis B or C virus infection. Tsai IT, et al. Cytokine, 2017 Feb. PMID 27770715
  4. Genetic variant in visfatin gene promoter contributes to reduced risk of hepatocellular carcinoma in a Chinese population. Wu Z, et al. Oncotarget, 2016 Nov 22. PMID 27792999, Free PMC Article
  5. Adipocytes as a source of increased circulating levels of nicotinamide phosphoribosyltransferase/visfatin in active acromegaly. Olarescu NC, et al. J Clin Endocrinol Metab, 2012 Apr. PMID 22319029

See all (661) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Association between visfatin and periodontitis: a systematic review and meta-analysis.
    Title: Association between visfatin and periodontitis: a systematic review and meta-analysis.
  2. [Mechanism and Clinical Significance of NAMPT in Multiple Myeloma].
    Title: [Mechanism and Clinical Significance of NAMPT in Multiple Myeloma].
  3. NAMPT promotes the malignant progression of HBV-associated hepatocellular carcinoma through activation of SREBP1-mediated lipogenesis.
    Title: NAMPT promotes the malignant progression of HBV-associated hepatocellular carcinoma through activation of SREBP1-mediated lipogenesis.
  4. Fibroblast growth factor-21 and Visfatin as potential predictors for metabolic risk factors in obese children.
    Title: Fibroblast growth factor-21 and Visfatin as potential predictors for metabolic risk factors in obese children.
  5. Association of Visfatin gene polymorphism with obesity related metabolic disorders among Pakistani population: a case control study.
    Title: Association of Visfatin gene polymorphism with obesity related metabolic disorders among Pakistani population: a case control study.
  6. Pathogenic role of NAMPT in the perivascular regions after ischemic stroke in mice with type 2 diabetes mellitus.
    Title: Pathogenic role of NAMPT in the perivascular regions after ischemic stroke in mice with type 2 diabetes mellitus.
  7. The importance of low visfatin values in osteoid osteoma patient: a prospective study.
    Title: The importance of low visfatin values in osteoid osteoma patient: a prospective study.
  8. The cytokine trio - visfatin, placental growth factor and fractalkine - and their role in myocardial infarction with non-obstructive coronary arteries (MINOCA).
    Title: The cytokine trio - visfatin, placental growth factor and fractalkine - and their role in myocardial infarction with non-obstructive coronary arteries (MINOCA).
  9. The Potential Role of Visfatin in Mediating Vascular Dysfunction and Hypertension.
    Title: The Potential Role of Visfatin in Mediating Vascular Dysfunction and Hypertension.
  10. Clock genes regulate skeletal muscle energy metabolism through NAMPT/NAD[+]/SIRT1 following heavy-load exercise.
    Title: Clock genes regulate skeletal muscle energy metabolism through NAMPT/NAD(+)/SIRT1 following heavy-load exercise.
Submit: New GeneRIF Correction See all GeneRIFs (543)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat-induced LTR transactivation is reversed by tanshinone II A through the AMPK-Nampt pathway PubMed
tat HIV-1 Tat-induced inhibition of NAMPT protein expression and depletion of NAD(+) levels in TZM-bl cells are reversed by tanshinone II A (a main lipid-soluble monomer derivative from the root of Salvia miltiorrhiza) PubMed
tat HIV-1 Tat upregulates miR-182 in TZM-bl cells. MiR-182 significantly inhibits NAMPT protein expression by acting on the 3'-UTR of the NAMPT mRNA PubMed
tat Tat causes NAD(+) depletion and inhibits Nicotinamide phosphoribosyltransferase (Nampt) mRNA and protein expression in cells. Nampt is critical in the regulation of Tat-induced inhibition of sirtuin 1 (SIRT1) activity and LTR transactivation PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC117256, DKFZp666B131

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nicotinamide phosphoribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nicotinamide phosphoribosyltransferase activity TAS
Traceable Author Statement
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in NAD biosynthesis via nicotinamide riboside salvage pathway TAS
Traceable Author Statement
more info
  
involved_in NAD biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT involved_in adipose tissue development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell-cell signaling TAS
Traceable Author Statement
more info
 PubMed 
involved_in circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
  
NOT involved_in insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell population proliferation TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cell junction IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
nicotinamide phosphoribosyltransferase
Names
NAmPRTase
pre-B cell-enhancing factor
pre-B-cell colony-enhancing factor 1
NP_005737.1
XP_047275655.1
XP_047275656.1
XP_054212959.1
XP_054212960.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005746.3 → NP_005737.1  nicotinamide phosphoribosyltransferase precursor

    See identical proteins and their annotated locations for NP_005737.1

    Status: REVIEWED

    Source sequence(s)
    AC007032, AI299587, BC106046, U02020
    Consensus CDS
    CCDS5737.1
    UniProtKB/Swiss-Prot
    A4D0Q9, A4D0R0, P43490, Q3KQV0, Q8WW95
    UniProtKB/TrEMBL
    A0A7P0T895
    Related
    ENSP00000222553.3, ENST00000222553.8
    Conserved Domains (1) summary
    cd01569
    Location:12 → 428
    PBEF_like; pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general, ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    106248298..106285888 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419699.1 → XP_047275655.1  nicotinamide phosphoribosyltransferase isoform X1

    UniProtKB/Swiss-Prot
    A4D0Q9, A4D0R0, P43490, Q3KQV0, Q8WW95
    Related
    ENSP00000390591.2, ENST00000424768.2

  2. XM_047419700.1 → XP_047275656.1  nicotinamide phosphoribosyltransferase isoform X2

    UniProtKB/TrEMBL
    A0A7P0T941
    Related
    ENSP00000505390.1, ENST00000681391.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    107563712..107602631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356984.1 → XP_054212959.1  nicotinamide phosphoribosyltransferase isoform X1

    UniProtKB/Swiss-Prot
    A4D0Q9, A4D0R0, P43490, Q3KQV0, Q8WW95

  2. XM_054356985.1 → XP_054212960.1  nicotinamide phosphoribosyltransferase isoform X2

    UniProtKB/TrEMBL
    A0A7P0T941

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_182790.1: Suppressed sequence

    Description
    NM_182790.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43490.1 GenPept UniProtKB/Swiss-Prot:P43490

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